Brain electrophysiological endophenotypes for externalizing psychopathology: a multivariate approach.
Brain electrophysiological endophenotypes for externalizing psychopathology: a multivariate approach.
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DOI：
10.1007/s10519-010-9343-3
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发表时间：
2010-03
影响因子：
2.6
通讯作者：
Iacono, William G.
中科院分区：
文献类型：
--
作者：
Gilmore, Casey S.;Malone, Stephen M.;Iacono, William G.
刺激诱发的脑活动的电生理测量异常（包括P3事件相关电位（ERP）及其相关的delta和theta时间频率（TF）成分），以及内在的静息状态脑活动（包括β频段的EEG）都与各种外化（EXT）频谱障碍的生物易感性相关，如物质使用障碍、行为障碍和反社会行为。虽然这些单独的测量都显示出作为EXT的一个或多个方面的内表型的希望，但我们提出，通过集体使用这些测量，可以增强识别EXT相关基因的能力。因此，我们试图探索一种多变量方法来识别与EXT相关的电生理内表型，使用文献中确定的EXT有希望的个体内表型。使用我们的大型双胞胎样本（634 MZ和335 DZ，男性和女性同性对）的数据，并拟合多变量生物识别Cholesky模型，我们发现这些措施1)是可遗传的；2)与EXT的一般易感性表现出显著的表型和遗传相关性（EXT本身具有高度遗传性），3)彼此之间表现出适度的表型和遗传相关性，4)对不同性别的遗传效应敏感。这些关系表明，这些内表型可能与神经生理过程和基因有关，这些过程和基因在它们之间既常见又独特——所有这些都与EXT精神病理学的生物脆弱性有关。
Abnormalities in electrophysiological measures of stimulus-evoked brain activity (including the P3 event-related potential (ERP) and its associated delta and theta time-frequency (TF) components), and intrinsic, resting state brain activity (including EEG in the beta frequency band) have each been associated with biological vulnerability to a variety of externalizing (EXT) spectrum disorders, such as substance use disorders, conduct disorder, and antisocial behavior. While each of these individual measures has shown promise as an endophenotype for one or more aspects of EXT, we proposed that the power to identify EXT-related genes may be enhanced by using these measures collectively. Thus, we sought to explore a multivariate approach to identifying electrophysiological endophenotypes related to EXT, using measures identified in the literature as promising individual endophenotypes for EXT. Using data from our large twin sample (634 MZ and 335 DZ, male and female same-sex pairs), and fitting multivariate biometric Cholesky models, we found that these measures 1) were heritable, 2) showed significant phenotypic and genetic correlation with a general vulnerability to EXT (which is itself highly heritable), 3) showed modest phenotypic and genetic correlation with each other, and 4) were sensitive to genetic effects that differed as a function of gender. These relationships suggest that these endophenotypes are likely tapping into neurophysiological processes and genes that are both common across them and unique to each – all of which are relevant to a biological vulnerability to EXT psychopathology.
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影响因子：
4.7
作者：
Clarke, AR;Barry, RJ;Croft, RJ
通讯作者：
Croft, RJ
影响因子：
4.2
作者：
Costa, L;Bauer, L
通讯作者：
Bauer, L
DOI：
10.1111/j.1530-0277.2008.00866.x
发表时间：
2009-03-01
影响因子：
3.2
作者：
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通讯作者：
Foroud, Tatiana
影响因子：
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作者：
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通讯作者：
Mikolaiewski, Amy J.
影响因子：
3
作者：
Bernat, Edward M.;Malone, Stephen M.;Iacono, William G.
通讯作者：
Iacono, William G.