The Diagnostic Value of (18)F-FDG PET/CT Bone Marrow Uptake Pattern in Detecting Bone Marrow Involvement in Pediatric Neuroblastoma Patients.
The Diagnostic Value of (18)F-FDG PET/CT Bone Marrow Uptake Pattern in Detecting Bone Marrow Involvement in Pediatric Neuroblastoma Patients.
复制标题
DOI：
10.1155/2022/7556315
复制
发表时间：
2022
影响因子：
--
通讯作者：
Yang J
中科院分区：
文献类型：
--
作者：
Liu J;Li C;Yang X;Lu X;Zhang M;Qian L;Wang W;Kan Y;Yang J
探讨 18F-FDG PET/CT 骨髓摄取模式 (BMUP) 对检测小儿神经母细胞瘤 (NB) 患者骨髓受累 (BMI) 的诊断价值。 98 名 NB 患者被纳入 BMI 分析。根据治疗前的 cF-FDG PET/CT 图像对骨髓摄取的四种模式进行分类。对一些关键检查指标和~(18)F-FDG PET/CT代谢参数进行分析。 BMUP 分为 BMUP1、BMUP2、BMUP3 和 BMUP4。比较骨髓和血液的配对样同源盒2b（PHOX2B）、骨髓活检（BMB）结果以及18F-FDG PET/CT来检测BMI。所有患者均接受至少六个月的随访。 不同医生之间的 BMUP 具有极好的一致性。两名住院医师和两名主治医师以及住院医师和主治医师之间的 Kappa 系数分别为 0.857、0.891 和 0.845。 SUVmax-骨/肝诊断BMUP3患者BMI的最佳截断值为2.08，曲线下面积（AUC）为0.873。骨髓PHOX2B（BM的PHOX2B）、血液PHOX2B、BMB和18F-FDG PET/CT的AUC分别为0.916、0.811、0.806和0.904。 BM和PET/CT的PHOX2B无显着差异。 PET/CT 诊断 BMI 的阳性预测值、阴性预测值、敏感性和特异性分别为 92.9%、92.9%、97.0% 和 83.9%，而 BM PHOX2B 诊断的阳性预测值、敏感性和特异性分别为 96.7%、80.6%、89.6% 和 93.5%。 治疗前18F-FDG PET/CT的BMUP是一种简单实用的方法，在检测BMI方面具有较高的诊断效率，可能会减少一些儿童NB患者不必要的侵入性检查。
To explore the diagnostic value of 18F-FDG PET/CT bone marrow uptake pattern (BMUP) in detecting bone marrow involvement (BMI) in pediatric neuroblastoma (NB) patients. Ninety-eight NB patients were enrolled in BMI analysis. Four patterns of bone marrow uptake were categorized based on pretreatment cF-FDG PET/CT images. Some crucial inspection indexes and 18F-FDG PET/CT metabolic parameters were analyzed. The BMUP was divided into BMUP1, BMUP2, BMUP3, and BMUP4. Paired-like homeobox 2b (PHOX2B) of bone marrow and blood, bone marrow biopsy (BMB) result, and 18F-FDG PET/CT were compared to detect BMI. All patients were followed up for at least six months. BMUP had excellent consistency among different physicians. Kappa coefficients of two residents and two attending physicians and between the resident and attending physician, were 0.857, 0.891, and 0.845, respectively. The optimal cut-off value of SUVmax-Bone/Liver was 2.08 to diagnose BMI for BMUP3 patients, and the area under curve (AUC) was 0.873. AUC of PHOX2B of bone marrow (PHOX2B of BM), PHOX2B of blood, BMB, and 18F-FDG PET/CT were 0.916, 0.811, 0.806, and 0.904, respectively. There was no significant difference between PHOX2B of BM and PET/CT. Positive predictive value, negative predictive value, sensitivity, and specificity in diagnosis of BMI were 92.9%, 92.9%, 97.0%, and 83.9% for PET/CT and 96.7%, 80.6%, 89.6%, and 93.5% for PHOX2B of BM, respectively. BMUP of pretreatment 18F-FDG PET/CT is a simple and practical method, which has a relatively high diagnostic efficiency in detecting BMI and might decrease unnecessary invasive inspections in some pediatric NB patients.
登录
查看更多内容
PET/CT 骨髓 FDG 摄取模式对新诊断弥漫性大 B 细胞淋巴瘤的预后价值
影响因子：
3.9
作者：
Chen Y;Zhou M;Liu J;Huang G
通讯作者：
Huang G
DOI：
10.1007/s00259-008-0911-1
发表时间：
2009-01-01
影响因子：
9.1
作者：
Kleis, Margit;Daldrup-Link, Heike;Franc, Benjamin L.
通讯作者：
Franc, Benjamin L.
影响因子：
6.6
作者：
Su Y;Wang L;Zhao Q;Yue Z;Zhao W;Wang X;Duan C;Jin M;Zhang D;Chen S;Yin J;Qiu L;Cheng X;Xu Z;Ma X
通讯作者：
Ma X
影响因子：
45.3
作者：
Monclair, Tom;Brodeur, Garrett M.;Pearson, Andrew D. J.
通讯作者：
Pearson, Andrew D. J.
影响因子：
3.2
作者：
Corrias, Maria V.;Parodi, Stefano;Burchill, Susan A.
通讯作者：
Burchill, Susan A.