Membrane-mediated interactions between hinge-like particles
Membrane-mediated interactions between hinge-like particles
复制标题
铰链状颗粒之间膜介导的相互作用
DOI：
10.1039/d2sm00094f
复制
发表时间：
2022
期刊：
影响因子：
3.4
通讯作者：
Abel, Steven M.
中科院分区：
文献类型：
--
作者：
Li, Bing;Abel, Steven M.
纳米颗粒在膜上的吸附可以引起由膜变形介导的颗粒之间的相互作用，其在自组装和膜重塑中起重要作用。以前的理论和实验研究主要集中在具有固定形状的纳米颗粒，如球形，棒状和弯曲的纳米颗粒。最近，铰链样DNA折纸纳米结构已被设计成具有可调的机械性能。受此启发，我们使用蒙特卡罗和伞形抽样模拟研究了吸附在弹性膜上的铰链状颗粒的平衡性质。一个孤立的颗粒的配置的影响，通过竞争的膜和颗粒的弯曲能，这可以通过改变吸附强度和铰链刚度控制。当两个吸附的颗粒相互作用时，当粘附到膜的强度较弱时，它们有效地彼此排斥。然而，强的粘附相互作用诱导颗粒之间的有效吸引力，这驱动它们的聚集。聚集体的配置可以通过调整铰链刚度来调整：柔性铰链发生尖端到尖端聚集，而刚性铰链也发生尖端到中间聚集。我们的研究结果突出了利用可变形纳米粒子的机械特性来影响它们的自组装的潜力，当粒子和膜相互影响时。
Adsorption of nanoparticles on a membrane can give rise to interactions between particles, mediated by membrane deformations, that play an important role in self-assembly and membrane remodeling. Previous theoretical and experimental research has focused on nanoparticles with fixed shapes, such as spherical, rod-like, and curved nanoparticles. Recently, hinge-like DNA origami nanostructures have been designed with tunable mechanical properties. Inspired by this, we investigate the equilibrium properties of hinge-like particles adsorbed on an elastic membrane using Monte Carlo and umbrella sampling simulations. The configurations of an isolated particle are influenced by competition between bending energies of the membrane and the particle, which can be controlled by changing adsorption strength and hinge stiffness. When two adsorbed particles interact, they effectively repel one another when the strength of adhesion to the membrane is weak. However, a strong adhesive interaction induces an effective attraction between the particles, which drives their aggregation. The configurations of the aggregate can be tuned by adjusting the hinge stiffness: tip-to-tip aggregation occurs for flexible hinges, whereas tip-to-middle aggregation also occurs for stiffer hinges. Our results highlight the potential for using the mechanical features of deformable nanoparticles to influence their self-assembly when the particles and membrane mutually influence one another.
DOI：
--
发表时间：
2006
期刊：
--
影响因子：
--
作者：
Iroon Polytechniou-
通讯作者：
Iroon Polytechniou-