Haptoglobin phenotype and apolipoprotein E polymorphism: relationship to posttraumatic seizures and neuropsychological functioning after traumatic brain injury.
Haptoglobin phenotype and apolipoprotein E polymorphism: relationship to posttraumatic seizures and neuropsychological functioning after traumatic brain injury.
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DOI：
10.1016/j.yebeh.2009.08.025
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发表时间：
2009-11
期刊：
影响因子：
--
通讯作者：
Sadrzadeh SM
中科院分区：
文献类型：
--
作者：
Anderson GD;Temkin NR;Dikmen SS;Diaz-Arrastia R;Machamer JE;Farhrenbruch C;Miller JW;Sadrzadeh SM
在之前的丙戊酸临床研究中，对创伤性脑损伤 (TBI) 患者进行了调查，研究了铁容量和载脂蛋白 E (APOE) 降低的遗传倾向与创伤后癫痫发作 (PTS) 和神经心理学结果之间的关系。 TBI 后约 10 年，在 25 名 PTS 和 26 名对照（无 PTS）受试者中测定了触珠蛋白 (Hp) 浓度/表型和 APOE 基因型。还对之前收集的 25 名其他 PTS 受试者和 32 名无 PTS 受试者的冷冻样本进行了 Hp 表型测定。 Hp表型或APOE基因型与PTS的发生无关。 APOE 基因型与神经心理学结果无关；然而，当根据教育水平差异进行调整时，APOE ε4 受试者的表现较差，尤其是在言语智力和言语记忆技能方面。与我们的假设相反，那些具有 Hp 1-1（血红蛋白高亲和力结合物）的人在受伤后 1 个月和 12 个月的语言 IQ 和 Taping D 得分稍差。
The relationship between genetic predisposition to reduced iron capacity and apolipoprotein E (APOE) with post-traumatic seizures (PTS) and neuropsychological outcomes was investigated in patients with traumatic brain injuries (TBI) from a prior valproate clinical study. Haptoglobin (Hp) concentration/phenotype and APOE genotype was determined in 25 PTS and 26 controls (no PTS) subjects ~10 year after TBI. Hp phenotype was also determined in previously collected frozen samples for 25 additional PTS and 32 no PTS subjects. There was no relationship between Hp phenotype or APOE genotype and occurrence of PTS. APOE genotype was not related to neuropsychological outcome; however when adjustments were made for differences in educational levels, APOE ε4 subjects did worse especially on verbal intellectual and verbal memory skills. In contrast to our hypothesis, those with Hp 1-1 (high affinity binder of hemoglobin), scored somewhat worse on verbal IQ and Tapping D at 1 and 12 month after injury.
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影响因子：
9.9
作者：
Chapman, J;Estupinan, J;Goldfarb, LG
通讯作者：
Goldfarb, LG
DOI：
10.1016/s0022-5371(73)80034-9
发表时间：
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期刊：
JOURNAL OF VERBAL LEARNING AND VERBAL BEHAVIOR
影响因子：
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作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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