Autoradiographic Analysis of [3H]Imipramine Binding in the Human Brain Postmortem: Effects of Age and Alcohol
Autoradiographic Analysis of [3H]Imipramine Binding in the Human Brain Postmortem: Effects of Age and Alcohol
复制标题
人脑死后[3H]丙咪嗪结合的放射自显影分析：年龄和酒精的影响
DOI：
10.1111/j.1471-4159.1988.tb01070.x
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发表时间：
1988
影响因子：
4.7
通讯作者：
A. Biegon
中科院分区：
文献类型：
--
作者：
R. Gross‐Isseroff;A. Biegon
Abstract: In vitro quantitative autoradiography of high‐affinity [3H]imipramine binding sites was performed on 16 human brains postmortem. The densities of binding sites were highest in the hypothalamus. Next, in descending order, were the basal and lateral nuclei of the amygdala; substantia innominata; insular cortex; the central nucleus of the amygdala; the anterior nucleus of the thalamus; the head of the caudate nucleus; portions of the frontal, parietal, and temporal cortex; claustrum; the granular layer of the dentate gyrus; substantia nigra; the pyramidal layer of CA fields; globus pallidus; red nucleus; and white matter. Imipramine binding was found to increase with age in a region‐specific manner. The presence of alcohol had a similar effect, which was most pronounced in the hippocampus. Sex and time from death to autopsy did not affect imipramine binding, in our sample.
年龄改变了雌性大鼠中观察到的丙咪嗪结合位点对长期抗抑郁治疗的反应。
影响因子：
5
作者：
Wilson,MA;Roy,EJ
通讯作者：
Roy,EJ