Synaptic inhibition of Purkinje cells mediates consolidation of vestibulo-cerebellar motor learning.
Synaptic inhibition of Purkinje cells mediates consolidation of vestibulo-cerebellar motor learning.
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DOI：
10.1038/nn.2348
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发表时间：
2009-08
影响因子：
25
通讯作者：
De Zeeuw, Chris I.
中科院分区：
文献类型：
--
作者：
Wulff, Peer;Schonewille, Martijn;Renzi, Massimiliano;Viltono, Laura;Sassoe-Pognetto, Marco;Badura, Aleksandra;Gao, Zhenyu;Hoebeek, Freek E.;van Dorp, Stijn;Wisden, William;Farrant, Mark;De Zeeuw, Chris I.
虽然对浦肯野细胞的前馈抑制在40年前首次被记录下来，但我们仍然对抑制性中间神经元如何影响行为动物的小脑功能知之甚少。使用小鼠品系（PC-Δγ2），选择性地从浦肯野细胞中去除GABAA受体介导的突触抑制，我们研究了分子层中间神经元的前馈抑制如何调节前庭-眼反射的适应。虽然基线运动表现的损害相对轻微，但适应前庭-眼反射阶段和巩固增益适应的能力却受到严重损害。浦肯野细胞表现出异常的简单尖峰模式，无论是在引起代偿性眼球运动期间还是在没有引起代偿性眼球运动时。基于实验数据的建模，我们提出前馈抑制通过控制浦肯野细胞活动的精细尺度模式，可以诱导小脑和前庭核神经元的可塑性。
Although feed-forward inhibition onto Purkinje cells was first documented forty years ago, we still understand little of how inhibitory interneurons contribute to cerebellar function in behaving animals. Using a mouse line (PC-Δγ2) in which GABAA receptor-mediated synaptic inhibition was selectively removed from Purkinje cells, we examined how feed-forward inhibition from molecular layer interneurons regulates adaptation of the vestibulo-ocular reflex. Whereas impairment of baseline motor performance was relatively mild, the ability to adapt the phase of the vestibulo-ocular reflex and to consolidate gain adaptations, was strongly compromised. Purkinje cells showed abnormal patterns of simple spikes, both during and in the absence of evoked compensatory eye movements. Based on modeling of the experimental data, we propose that feed-forward inhibition, by controlling the fine scale patterns of Purkinje cell activity, enables the induction of plasticity in neurons of the cerebellar and vestibular nuclei.
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影响因子：
16.2
作者：
Brunel, N;Hakim, V;Barbour, B
通讯作者：
Barbour, B
影响因子：
5.3
作者：
Kassardjian, CD;Tan, YF;Broussard, DM
通讯作者：
Broussard, DM
影响因子：
25
作者：
Lamsa, K;Heeroma, JH;Kullmann, DM
通讯作者：
Kullmann, DM
DOI：
10.1523/jneurosci.0559-08.2008
发表时间：
2008-07-23
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Davie JT;Clark BA;Häusser M
通讯作者：
Häusser M
影响因子：
16.2
作者：
Hansel, Christian;de Jeu, Marcel;Elgersma, Ype
通讯作者：
Elgersma, Ype