New Progress on the Role of Glia in Iron Metabolism and Iron-Induced Degeneration of Dopamine Neurons in Parkinson's Disease.
New Progress on the Role of Glia in Iron Metabolism and Iron-Induced Degeneration of Dopamine Neurons in Parkinson's Disease.
复制标题
神经胶质细胞在帕金森病铁代谢及铁诱导多巴胺神经元变性中的作用新进展
DOI：
10.3389/fnmol.2017.00455
复制
发表时间：
2017
影响因子：
4.8
通讯作者：
Xie J
中科院分区：
文献类型：
--
作者：
Xu H;Wang Y;Song N;Wang J;Jiang H;Xie J
现在越来越多的人认识到神经胶质细胞在铁稳态调节中起着关键作用。这些特性的损害可能导致铁代谢功能障碍和神经元的神经变性。我们之前的研究表明，神经胶质细胞功能障碍可能导致帕金森病（PD）患者的铁沉积，并增强铁诱导的多巴胺（DA）神经元变性。近年来，关于胶质细胞铁代谢及其对PD中DA神经元铁积累和变性的影响的知识也有了实质性的增长。在此，我们试图描述胶质细胞铁代谢的作用，以及胶质细胞对PD黑质DA神经元铁积累和变性的影响。这将为揭示PD中DA神经元铁积累的机制提供证据，并为发现PD新的潜在治疗靶点提供基础。
It is now increasingly appreciated that glial cells play a critical role in the regulation of iron homeostasis. Impairment of these properties might lead to dysfunction of iron metabolism and neurodegeneration of neurons. We have previously shown that dysfunction of glia could cause iron deposit and enhance iron-induced degeneration of dopamine (DA) neurons in Parkinson’s disease (PD). There also has been a substantial growth of knowledge regarding the iron metabolism of glia and their effects on iron accumulation and degeneration of DA neurons in PD in recent years. Here, we attempt to describe the role of iron metabolism of glia and the effect of glia on iron accumulation and degeneration of DA neurons in the substantia nigra of PD. This could provide evidence to reveal the mechanisms underlying nigral iron accumulation of DA neurons in PD and provide the basis for discovering new potential therapeutic targets for PD.
登录
查看更多内容
影响因子：
2.9
作者：
Bouwmans AE;Vlaar AM;Mess WH;Kessels A;Weber WE
通讯作者：
Weber WE
影响因子：
6.1
作者：
Brück D;Wenning GK;Stefanova N;Fellner L
通讯作者：
Fellner L
影响因子：
2.9
作者：
CABRERA, OEE;BONGARZONE, ER;PASQUINI, JM
通讯作者：
PASQUINI, JM
影响因子：
9.3
作者：
Cherry JD;Olschowka JA;O'Banion MK
通讯作者：
O'Banion MK
影响因子：
3.3
作者：
Carvey, PM;Chen, EY;Ling, ZD
通讯作者：
Ling, ZD