Ets-1 maintains IL-7 receptor expression in peripheral T cells.
Ets-1 maintains IL-7 receptor expression in peripheral T cells.
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DOI：
10.4049/jimmunol.1002099
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发表时间：
2011-01-15
期刊：
影响因子：
--
通讯作者：
Ho IC
中科院分区：
文献类型：
--
作者：
Grenningloh R;Tai TS;Frahm N;Hongo TC;Chicoine AT;Brander C;Kaufmann DE;Ho IC
CD 127（IL-7受体的IL-7结合亚基）的表达在T细胞的发育和活化过程中受到严格调节，并在慢性病毒感染过程中减少。然而，调控CD 127动态表达的分子机制仍然知之甚少。在这里，我们报告说，转录因子Ets-1是需要维持小鼠外周血T细胞中的CD 127的表达。Ets-1结合并激活CD 127启动子，其缺失导致CD 127表达降低、IL-7信号传导减弱和T细胞的IL-7依赖性稳态增殖受损。CD 127和Ets-1的表达在人T细胞中强烈相关。在HIV感染期间，CD 8 + T细胞中的CD 127和Ets-1表达均降低。此外，HIV相关的CD 127丢失仅在Ets-1低效应记忆和中央记忆中观察到，但在Ets-1高初始CD 8 + T细胞中未观察到。总之，我们的数据确定Ets-1作为T细胞中CD 127表达的关键调节因子。
The expression of CD127, the IL-7 binding subunit of the IL-7 receptor, is tightly regulated during the development and activation of T cells and is reduced during chronic viral infection. However, the molecular mechanism regulating the dynamic expression of CD127 is still poorly understood. Here we report that the transcription factor Ets-1 is required for maintaining the expression of CD127 in murine peripheral T cells. Ets-1 binds to and activates the CD127 promoter, and its absence leads to reduced CD127 expression, attenuated IL-7 signaling, and impaired IL-7-dependent homeostatic proliferation of T cells. The expression of CD127 and Ets-1 is strongly correlated in human T cells. Both CD127 and Ets-1 expression are decreased in CD8+ T cells during HIV infection. In addition, HIV-associated loss of CD127 is only observed in Ets-1low effector memory and central memory but not in Ets-1high naïve CD8+ T cells. Taken together, our data identify Ets-1 as a critical regulator of CD127 expression in T cells.
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DOI：
10.1084/jem.20071133
发表时间：
2008-05-12
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Tajima M;Wakita D;Noguchi D;Chamoto K;Yue Z;Fugo K;Ishigame H;Iwakura Y;Kitamura H;Nishimura T
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影响因子：
4.4
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影响因子：
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作者：
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DOI：
10.1073/pnas.95.5.2486
发表时间：
1998-03-03
影响因子：
11.1
作者：
Akashi, K;Kondo, M;Weissman, IL
通讯作者：
Weissman, IL