Regulation of human mesangial cell collagen expression by transforming growth factor-β1.
Regulation of human mesangial cell collagen expression by transforming growth factor-β1.
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通过转化生长因子-β1 调节人系膜细胞胶原表达。
DOI：
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
H. W. Schnaper
中科院分区：
文献类型：
--
作者：
A. Poncelet;H. W. Schnaper
Transforming growth factor (TGF)-β1 has been implicated in glomerular extracellular matrix accumulation. Since the spectrum and mechanism of changes in collagen turnover have not been fully characterized, we evaluated effects of TGF-β1 on collagen expression by human mesangial cells. TGF-β1 induced increased α1(I), α1(III), and α1(IV) collagen mRNA expression. Greater mRNA expression of matrix metalloproteinase (MMP)-2 was compensated by increased tissue inhibitor of metalloproteinases (TIMP)-2 mRNA. There was no change in TIMP-1 or membrane-type MMP mRNA expression, whereas MMP-1 mRNA decreased. Types I and IV collagen protein accumulated in both the cell layer and medium. Changes in collagen mRNA and protein occurred within 4 and 8 h, respectively. MMP-2 and TIMP-1 and -2 activities showed little change. Cycloheximide markedly decreased collagen detection within 4 h and reversed late, but not early, changes in α1(I) collagen mRNA. In this system, increased synthesis may be more significant than degradation for collagen accumulation, but collagen is short-lived in culture. Diverse TGF-β1 actions on collagen turnover may be either immediate or mediated through synthesis of regulatory molecules.
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影响因子：
19.6
作者：
S. Tomooka;W. A. Border;B. C. Marshall;N. Noble
通讯作者：
S. Tomooka;W. A. Border;B. C. Marshall;N. Noble
转化生长因子-β 1 刺激肾小球系膜细胞合成 72-kd IV 型胶原酶。
DOI：
--
发表时间：
1994
期刊：
The American journal of pathology
影响因子：
--
作者：
Marti,HP;Lee,L;Kashgarian,M;Lovett,DH
通讯作者：
Lovett,DH
DOI：
10.1172/jci113996
发表时间：
1989
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
MacKay,K;Striker,LJ;Stauffer,JW;Doi,T;Agodoa,LY;Striker,GE
通讯作者：
Striker,GE
DOI：
10.1073/pnas.90.5.1814
发表时间：
1993-03-01
影响因子：
11.1
作者：
YAMAMOTO, T;NAKAMURA, T;BORDER, WA
通讯作者：
BORDER, WA
影响因子：
15.9
作者：
OKUDA, S;LANGUINO, LR;BORDER, WA
通讯作者：
BORDER, WA