Understanding Asthma Phenotypes, Endotypes, and Mechanisms of Disease.
Understanding Asthma Phenotypes, Endotypes, and Mechanisms of Disease.
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DOI：
10.1007/s12016-018-8712-1
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发表时间：
2019-04
影响因子：
9.1
通讯作者：
Lee GB
中科院分区：
文献类型：
--
作者：
Kuruvilla ME;Lee FE;Lee GB
哮喘作为一个单一实体的模型现在已经被一个更复杂的生物网络所取代，这个网络由不同的和相互关联的炎症通路组成。术语哮喘现在被认为是具有不同机制途径（内型）和可变临床表现（表型）的几种疾病的总括诊断。由于固有的治疗和预后意义，这些内型的精确定义是哮喘管理的核心。本文就哮喘患者气道炎症异质性的分子机制作一综述。哮喘内源型可以广泛地被认为是2型（T2）高或T2低。几种生物制剂已被批准用于T2高哮喘，许多其他治疗药物是初期的，类似地针对特定的分子机制。总的来说，这些进展已经改变了哮喘治疗方法的现有范式，以定制新的治疗方法。
The model of asthma as a single entity has now been replaced by a much more complex biological network of distinct and interrelating inflammatory pathways. The term asthma is now considered an umbrella diagnosis for several diseases with distinct mechanistic pathways (endotypes) and variable clinical presentations (phenotypes). The precise definition of these endotypes is central to asthma management due to inherent therapeutic and prognostic implications. This review presents the molecular mechanisms behind the heterogeneity of airway inflammation in asthmatic patients. Asthma endotypes may be broadly regarded as type 2 (T2) high or T2-low. Several biologic agents have been approved for T2-high asthma, with numerous other therapeutics that are incipient and similarly targeted at specific molecular mechanisms. Collectively, these advances have shifted existing paradigms in the approach to asthma to tailor novel therapies.
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影响因子：
30.5
作者：
Bertin S;Aoki-Nonaka Y;de Jong PR;Nohara LL;Xu H;Stanwood SR;Srikanth S;Lee J;To K;Abramson L;Yu T;Han T;Touma R;Li X;González-Navajas JM;Herdman S;Corr M;Fu G;Dong H;Gwack Y;Franco A;Jefferies WA;Raz E
通讯作者：
Raz E
影响因子：
14.2
作者：
Fajt, Merritt L.;Gelhaus, Stacy L.;Freeman, Bruce;Uvalle, Crystal E.;Trudeau, John B.;Holguin, Fernando;Wenzel, Sally E.
通讯作者：
Wenzel, Sally E.
影响因子：
168.9
作者：
Guarnieri, Michael;Balmes, John R.
通讯作者：
Balmes, John R.
影响因子：
158.5
作者：
Corren, Jonathan;Lemanske, Robert F., Jr.;Matthews, John G.
通讯作者：
Matthews, John G.
DOI：
10.1164/rccm.201604-0866oc
发表时间：
2017-05-15
影响因子：
24.7
作者：
Bigler, Jeannette;Boedigheimer, Michael;Djukanovic, Ratko
通讯作者：
Djukanovic, Ratko