POLYGENIC MUTATION IN DROSOPHILA MELANOGASTER: ESTIMATES FROM DIVERGENCE AMONG INBRED STRAINS
POLYGENIC MUTATION IN DROSOPHILA MELANOGASTER: ESTIMATES FROM DIVERGENCE AMONG INBRED STRAINS
复制标题
果蝇的多基因突变：来自近交系之间差异的估计
DOI：
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发表时间：
1992
期刊：
影响因子：
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通讯作者：
W. G. Hill
中科院分区：
文献类型：
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作者：
T. Mackay;R. F. Lyman;M. Jackson;C. Terzian;W. G. Hill
将一个高度近交系的黑腹果蝇分为25个重复亚系，每代独立保持100代，每代10对未选择的果蝇。根据30-100世代10个世代亚系间的差异，以及65代以上突变累积后各亚系对差异选择的反应，估算了腹部和胸膜刷毛两个数量性状的多基因突变率(Vm)。根据品系间的差异和品系内对选择的反应估计的雌雄平均Vm分别为腹毛3.3×10-3VE和胸膜毛1.5×10-3VE，其中VE是环境差异。如果这些性状处于稳定选择下，并且如果影响刷毛数量的突变对适合度有有害影响，则影响这些性状的突变的实际产生速度可能要高得多。性别×突变体效应互作有很大的变异分量，亚系在腹毛数量的性别二态上进化出极显著的突变变异。多效性效应可能是决定刷毛数目的基因座突变的普遍特征。
A highly inbred line of Drosophila melanogaster was subdivided into 25 replicate sublines, which were independently maintained for 100 generations with 10 pairs of unselected flies per generation. The polygenic mutation rate (VM) for two quantitative traits, abdominal and sternopleural bristle number, was estimated from divergence among sublines at 10 generation intervals from generations 30‐100, and from response of each line to divergent selection after more than 65 generations of mutation accumulation. Estimates of VM averaged over males and females both from divergence among lines and from response to selection within lines were 3.3 × 10‐3 VE for abdominal bristles and 1.5 × 10‐3 VE for sternopleural bristles, where VE is the environmental variance. The actual rate of production of mutations affecting these traits may be considerably higher if the traits are under stabilizing selection, and if mutations affecting bristle number have deleterious effects on fitness. There was a substantial component of variance for sex × mutant effect interaction and the sublines evolved highly significant mutational variation in sex dimorphism of abdominal bristle number. Pleiotropic effects on sex dimorphism may be a general property of mutations at loci determining bristle number.
果蝇性别决定信号的分子性质及其与神经发生的联系。
DOI：
10.1126/science.1900130
发表时间：
1991
期刊：
Science (New York, N.Y.)
影响因子：
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作者：
Erickson,JW;Cline,TW
通讯作者：
Cline,TW