The emerging role of speckle-type POZ protein (SPOP) in cancer development.
The emerging role of speckle-type POZ protein (SPOP) in cancer development.
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DOI：
10.1016/j.drudis.2014.07.009
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发表时间：
2014-09
影响因子：
7.4
通讯作者：
Mani, Ram-Shankar
中科院分区：
文献类型：
--
作者：
Mani, Ram-Shankar
Speckle-type POZ (pox virus and zinc finger protein) protein (SPOP) is an E3 ubiquitin ligase adaptor protein that is frequently mutated in prostate and endometrial cancers. All the cancer-associated SPOP mutations reported to date are clustered in the meprin and TRAF homology (MATH) domain, presumably affecting substrate binding. SPOP mutations in prostate cancer are mutually exclusive with the ETS family gene rearrangements and define a distinct molecular subclass of prostate cancer. SPOP mutations contribute to prostate cancer development by altering the steady-state levels of key components in the androgen-signaling pathway.
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DOI：
10.1083/jcb.112.5.785
发表时间：
1991-03
期刊：
The Journal of cell biology
影响因子：
--
作者：
Ascoli CA;Maul GG
通讯作者：
Maul GG
影响因子：
4.8
作者：
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影响因子：
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通讯作者：
Bell, Daphne W.
影响因子：
64.5
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Sawyers CL
影响因子：
64.8
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通讯作者：
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