A critical evaluation of QIDS-SR-16 using data from a trial of psilocybin therapy versus escitalopram treatment for depression.
A critical evaluation of QIDS-SR-16 using data from a trial of psilocybin therapy versus escitalopram treatment for depression.
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DOI：
10.1177/02698811231167848
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发表时间：
2023-07
影响因子：
4.1
通讯作者：
Carhart-Harris, Robin L.
中科院分区：
文献类型：
--
作者：
Weiss, Brandon;Erritzoe, David;Giribaldi, Bruna;Nutt, David J.;Carhart-Harris, Robin L.
在最近的一项临床试验中，研究了裸盖菇素治疗（PT）与艾司西酞普兰治疗（ET）对重度抑郁症的疗效比较，16项主要疗效结局指标中有14项的结果有利于PT，但抑郁症状快速量表，自我报告，16项（QIDS-SR 16）没有。本研究的目的是（1）合理和心理测量解释结果测量之间的差异结果和（2）克服心理测量的问题，特别是个别措施，通过重新检查之间的条件差异，抑郁反应使用所有的结果测量项目，方面，和因素水平的分析。四个抑郁症的措施进行了比较，其有效性的基础上，检查PT和ET条件之间的抑郁反应的差异。QIDS-SR 16的不一致发现的可能原因包括其较高的方差，由于复合项目和全量表和一维总和评分的不精确性，项目评分选项的措辞不准确，以及缺乏对核心抑郁因素的关注。在项目水平、分面水平和因子水平上重新分析试验数据，结果提示PT在减少抑郁情绪、快感缺乏和核心抑郁因子方面具有上级疗效，沿着特定症状，如性功能障碍。我们的研究结果引起了对QIDS-SR 16测量抑郁症的充分性的关注，以及依赖于倾向于不捕捉抑郁症的多维结构或核心的个体量表的做法。使用另一种方法，捕捉抑郁症更颗粒和全面产生具体的洞察领域PT治疗可能是特别有用的患者和临床医生。
In a recent clinical trial examining the comparative efficacy of psilocybin therapy (PT) versus escitalopram treatment (ET) for major depressive disorder, 14 of 16 major efficacy outcome measures yielded results that favored PT, but the Quick Inventory of Depressive Symptomatology, Self-Report, 16 items (QIDS-SR16) did not. The present study aims to (1) rationally and psychometrically account for discrepant results between outcome measures and (2) to overcome psychometric problems particular to individual measures by re-examining between-condition differences in depressive response using all outcome measures at item-, facet-, and factor-levels of analysis. Four depression measures were compared on the basis of their validity for examining differences in depressive response between PT and ET conditions. Possible reasons for discrepant findings on the QIDS-SR16 include its higher variance, imprecision due to compound items and whole-scale and unidimensional sum-scoring, vagueness in the phrasing of scoring options for items, and its lack of focus on a core depression factor. Reanalyzing the trial data at item-, facet-, and factor-levels yielded results suggestive of PT’s superior efficacy in reducing depressed mood, anhedonia, and a core depression factor, along with specific symptoms such as sexual dysfunction. Our results raise concerns about the adequacy of the QIDS-SR16 for measuring depression, as well as the practice of relying on individual scales that tend not to capture the multidimensional structure or core of depression. Using an alternative approach that captures depression more granularly and comprehensively yielded specific insight into areas where PT therapy may be particularly useful to patients and clinicians.
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影响因子：
3.2
作者：
Ahmadpanah, Mohammad;Sheikhbabaei, Meisam;Brand, Serge
通讯作者：
Brand, Serge
影响因子：
6.6
作者：
Fried, Eiko I.
通讯作者：
Fried, Eiko I.
DOI：
10.1146/annurev-clinpsy-050212-185608
发表时间：
2013-01-01
期刊：
ANNUAL REVIEW OF CLINICAL PSYCHOLOGY, VOL 9
影响因子：
--
作者：
Borsboom, Denny;Cramer, Angelique O. J.
通讯作者：
Cramer, Angelique O. J.
影响因子：
3.6
作者：
Fried, Eiko I.;van Borkulo, Claudia D.;Borsboom, Denny
通讯作者：
Borsboom, Denny
影响因子：
3.7
作者：
Carhart-Harris RL;Mayberg HS;Malizia AL;Nutt D
通讯作者：
Nutt D