Perspectives on cancer stem cells in osteosarcoma.
Perspectives on cancer stem cells in osteosarcoma.
复制标题
骨肉瘤中癌症干细胞的观点。
DOI：
10.1016/j.canlet.2012.05.028
复制
发表时间：
2013-09-10
期刊：
影响因子：
9.7
通讯作者：
Mansukhani, Alka
中科院分区：
文献类型：
--
作者：
Basu-Roy, Upal;Basilico, Claudio;Mansukhani, Alka
关键词：
骨肉瘤是一种侵袭性的儿科肿瘤，生长的骨骼，尽管手术和化疗，是容易复发。这些间充质肿瘤来源于成骨细胞谱系中的祖细胞，这些祖细胞积累了突变以逃避细胞周期检查点，导致过度增殖和适当分化为成熟骨形成成骨细胞的能力缺陷。与其他恶性肿瘤一样，骨肉瘤通常是异质性的，由具有不同分化阶段特征的表型不同的细胞组成。癌症干细胞假说认为肿瘤是由干细胞维持的，并且是肿瘤起始干细胞的难治性群体的不完全根除导致了耐药性和肿瘤复发。在这篇综述中，我们提出了我们目前的知识，从小鼠和人类肿瘤的骨肉瘤干细胞的生物学，突出新的见解和未解决的问题，在这个难以捉摸的人口的识别。我们专注于维持这些细胞的因素和途径，以及与上皮癌范例的差异。靶向骨肉瘤中的癌症干细胞是探索开发这种毁灭性儿童癌症的新疗法的一条有希望的途径。
Osteosarcoma is an aggressive pediatric tumor of growing bones that, despite surgery and chemotherapy, is prone to relapse. These mesenchymal tumors are derived from progenitor cells in the osteoblast lineage that have accumulated mutations to escape cell cycle checkpoints leading to excessive proliferation and defects in their ability to differentiate appropriately into mature bone-forming osteoblasts. Like other malignant tumors, osteosarcoma is often heterogeneous, consisting of phenotypically distinct cells with features of different stages of differentiation. The cancer stem cell hypothesis posits that tumors are maintained by stem cells and it is the incomplete eradication of a refractory population of tumor-initiating stem cells that accounts for drug resistance and tumor relapse. In this review we present our current knowledge about the biology of osteosarcoma stem cells from mouse and human tumors, highlighting new insights and unresolved issues in the identification of this elusive population. We focus on factors and pathways that are implicated in maintaining such cells, and differences from paradigms of epithelial cancers. Targeting of the cancer stem cells in osteosarcoma is a promising avenue to explore to develop new therapies for this devastating childhood cancer.
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影响因子：
3.7
作者：
Fuerer C;Nusse R
通讯作者：
Nusse R
影响因子：
64.8
作者：
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通讯作者：
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影响因子：
5.2
作者：
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通讯作者：
Takakura, Yoshinori
DOI：
10.1073/pnas.0805462105
发表时间：
2008-08-19
影响因子：
11.1
作者：
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通讯作者：
Lees, Jacqueline A.
影响因子：
5.7
作者：
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通讯作者：
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