Outcome of SARS-CoV-2 Infection in 121 Patients with Inborn Errors of Immunity: A Cross-Sectional Study.
Outcome of SARS-CoV-2 Infection in 121 Patients with Inborn Errors of Immunity: A Cross-Sectional Study.
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DOI：
10.1007/s10875-021-01066-8
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发表时间：
2021-10
影响因子：
9.1
通讯作者：
Grumach AS
中科院分区：
文献类型：
--
作者：
Goudouris ES;Pinto-Mariz F;Mendonça LO;Aranda CS;Guimarães RR;Kokron C;Barros MT;Anísio F;Alonso MLO;Marcelino F;Valle SOR;Junior SD;Barreto IDP;Ferreira JFS;Roxo-Junior P;do Rego Silva AM;Campinhos FL;Bonfim C;Loth G;Fernandes JF;Garcia JL;Capelo A;Takano OA;Nadaf MIV;Toledo EC;Cunha LAO;Di Gesu RSW;Schidlowski L;Fillipo P;Bichuetti-Silva DC;Soldateli G;Ferraroni NR;de Oliveira Dantas E;Pestana S;Mansour E;Ulaf RG;Prando C;Condino-Neto A;Grumach AS
关于先天性免疫错误（IEI）患者感染SARS-CoV-2的数据仍然很少，还有许多未解决的问题。我们的目的是描述巴西IEI患者SARS-CoV-2感染的临床结局，并确定影响感染的因素。我们进行了一项横断面、多中心研究，包括受IEI和SARS-CoV-2感染影响的任何年龄的患者。研究的变量包括性别、年龄、IEI类型、合并症（数量和类型）、IEI治疗方法、临床表现和SARS-CoV-2感染的严重程度。纳入121例患者：55.4%为女性，年龄6个月至74岁（中位年龄25.1岁）。大多数患者以抗体缺乏为主（n = 53）。感染多为无症状（21例）和轻度（66例），1例患儿出现多系统炎症综合征（MIS-C）。我们没有观察到与性别相关的易感性，年龄与感染严重程度之间存在弱相关性。合并症的数量在严重病例中较高，特别是支气管扩张和心脏病。遗传性血管性水肿患者无重症病例。6例2至74岁的患者死亡，其中3例为抗体缺乏。大多数患者的预后较轻，但病死率高于一般人群。然而，除了与轻度COVID-19相关的补体缺乏外，IEI的类型并不是严重程度的决定性因素。SARS-CoV-2感染的严重程度似乎与年龄、合并症的数量和合并症的类型（支气管扩张和心脏病）更相关。在线版本包含补充材料，可在10.1007/s10875-021-01066-8获得。
There is still scarce data on SARS-CoV-2 infection in patients with Inborn Errors of Immunity (IEI) and many unresolved questions. We aimed to describe the clinical outcome of SARS-CoV-2 infection in Brazilian IEI patients and identify factors influencing the infection. We did a cross-sectional, multicenter study that included patients of any age affected by IEI and SARS-CoV-2 infection. The variables studied were sex, age, type of IEI, comorbidities (number and type), treatment in use for IEI, clinical manifestations and severity of SARS-CoV-2 infection. 121 patients were included: 55.4% female, ages from six months to 74 yo (median age = 25.1 yo). Most patients had predominantly antibody deficiency (n = 53). The infection was mostly asymptomatic (n = 21) and mild (n = 66), and one child had multisystem inflammatory syndrome (MIS-C). We could not observe sex-related susceptibility, and there was a weak correlation between age and severity of infection. The number of comorbidities was higher in severe cases, particularly bronchiectasis and cardiopathy. There were no severe cases in hereditary angioedema patients. Six patients aged 2 to 74 years died, three of them with antibody deficiency. The outcome was mild in most patients, but the Case Fatality Ratio was higher than in the general population. However, the type of IEI was not a determining factor for severity, except for complement deficiencies linked to milder COVID-19. The severity of SARS-CoV-2 infection seems to be more related to older age, a higher number of comorbidities and type of comorbidities (bronchiectasis and cardiopathy). The online version contains supplementary material available at 10.1007/s10875-021-01066-8.
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DOI：
10.1016/j.jaip.2020.11.006
发表时间：
2021-01
期刊：
The journal of allergy and clinical immunology. In practice
影响因子：
--
作者：
Cohen B;Rubinstein R;Gans MD;Deng L;Rubinstein A;Eisenberg R
通讯作者：
Eisenberg R
影响因子：
11.8
作者：
Andersen, Kathleen M.;Mehta, Hemalkumar B.;Alexander, G. Caleb
通讯作者：
Alexander, G. Caleb
DOI：
10.1016/j.jaip.2020.11.042
发表时间：
2021-01
期刊：
The journal of allergy and clinical immunology. In practice
影响因子：
--
作者：
Grumach AS;Goudouris E;Dortas Junior S;Marcelino FC;Alonso MLO;Martins RO;Arpon MA;Valle SOR
通讯作者：
Valle SOR
影响因子：
7.3
作者：
Marcus N;Frizinsky S;Hagin D;Ovadia A;Hanna S;Farkash M;Maoz-Segal R;Agmon-Levin N;Broides A;Nahum A;Rosenberg E;Kuperman AA;Dinur-Schejter Y;Berkun Y;Toker O;Goldberg S;Confino-Cohen R;Scheuerman O;Badarneh B;Epstein-Rigbi N;Etzioni A;Dalal I;Somech R
通讯作者：
Somech R
影响因子：
14.2
作者：
Lee, Pui Y.;Platt, Craig D.;Chou, Janet
通讯作者：
Chou, Janet