LINC complexes form by binding of three KASH peptides to domain interfaces of trimeric SUN proteins.
LINC complexes form by binding of three KASH peptides to domain interfaces of trimeric SUN proteins.
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DOI：
10.1016/j.cell.2012.03.046
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发表时间：
2012-05-25
期刊：
影响因子：
64.5
通讯作者：
Schwartz TU
中科院分区：
文献类型：
--
作者：
Sosa BA;Rothballer A;Kutay U;Schwartz TU
Linker of Nucleoskeleton and Cytoskeleton (LINC) complexes span the nuclear envelope and are composed of KASH and SUN proteins residing in the outer and inner nuclear membrane, respectively. LINC formation relies on direct binding of KASH and SUN in the perinuclear space. Thereby, molecular tethers are formed that can transmit forces for chromosome movements, nuclear migration and anchorage. We present crystal structures of the human SUN2-KASH1/2 complex, the core of the LINC complex. The SUN2 domain is rigidly attached to a trimeric coiled-coil that prepositions it to bind three KASH peptides. The peptides bind in three deep and expansive grooves formed between adjacent SUN domains, effectively acting as molecular glue. In addition, a disulfide between conserved cysteines on SUN and KASH covalently links both proteins. The structure provides the basis of LINC complex formation and suggests a model for how LINC complexes might arrange into higher-order clusters to enhance force-coupling.
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影响因子：
7.5
作者：
Onischenko, Evgeny;Weis, Karsten
通讯作者：
Weis, Karsten
在发育，减数分裂和疾病期间，太阳结构域和kash域蛋白质。
DOI：
10.1007/s00018-008-8713-y
发表时间：
2009-05
期刊：
Cellular and molecular life sciences : CMLS
影响因子：
--
作者：
Fridkin A;Penkner A;Jantsch V;Gruenbaum Y
通讯作者：
Gruenbaum Y
DOI：
10.1073/pnas.0304375101
发表时间：
2004-01-20
影响因子：
11.1
作者：
Goodchild, RE;Dauer, WT
通讯作者：
Dauer, WT
影响因子：
64.5
作者：
Chikashige, Y;Tsutsumi, C;Hiraoka, Y
通讯作者：
Hiraoka, Y
DOI：
10.1016/j.bbamcr.2008.09.001
发表时间：
2008-12-01
影响因子：
5.1
作者：
Lu, Wenshu;Gotzmann, Josef;Karakesisoglou, Iakowos
通讯作者：
Karakesisoglou, Iakowos