FDG-PET SUVmax combined with IASLC/ATS/ERS histologic classification improves the prognostic stratification of patients with stage I lung adenocarcinoma.
FDG-PET SUVmax combined with IASLC/ATS/ERS histologic classification improves the prognostic stratification of patients with stage I lung adenocarcinoma.
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FDG-PET SUVMAX与IASLC/ATS/ERS组织学分类相结合，改善了I期肺腺癌患者的预后分层。
DOI：
10.1245/s10434-012-2414-3
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发表时间：
2012-10
影响因子：
3.7
通讯作者：
Adusumilli PS
中科院分区：
文献类型：
--
作者：
Kadota K;Colovos C;Suzuki K;Rizk NP;Dunphy MP;Zabor EC;Sima CS;Yoshizawa A;Travis WD;Rusch VW;Adusumilli PS
我们研究了新提出的国际肺癌研究协会(IASLC)/美国胸科学会(ATS)/欧洲呼吸学会（ERS）分类与正电子发射断层扫描（PET）上18f -氟脱氧葡萄糖（FDG）摄取之间的关系，以及这些放射学和病理因素的联合是否可以进一步对I期肺腺癌患者进行预后分层。我们回顾性评估了1999年至2005年间222例在手术切除前接受FDG-PET扫描的病理I期肺腺癌患者。根据IASLC/ATS/ERS分级（低、中、高）和最大标准摄取值（SUVmax）（低<3.0，高≥3.0）对患者进行组织学分级。累积复发率（CIR）用于估计复发概率。高级别组织学患者的复发风险（5年CIR， 29% [n = 25]）高于中度（13% [n = 181]）或低级别（11% [n = 16]）组织学患者（p = 0.046）。与低SUVmax相比，高SUVmax与高级别组织学相关（p < 0.001），并且复发风险增加（5年CIR， 21% [n = 113]对8% [n = 109]; p = 0.013）。在中等组织学分级的患者中，SUVmax高的患者复发风险高于SUVmax低的患者（5年CIR， 19% [n = 87] vs. 7% [n = 94]; p = 0.033）。调整病理分期后，SUVmax与复发相关（p = 0.037）。FDG-PET的SUVmax与IASLC/ATS/ERS分级相关，可用于将中度组织学（主要组织学亚型）患者分为两个预后亚组。
We investigated the association between the newly proposed International Association for the Study of Lung Cancer (IASLC)/American Thoracic Society (ATS)/European Respiratory Society (ERS) classification and 18F-fluorodeoxyglucose (FDG) uptake on positron emission tomography (PET), and whether the combination of these radiologic and pathologic factors can further prognostically stratify patients with stage I lung adenocarcinoma. We retrospectively evaluated 222 patients with pathologic stage I lung adenocarcinoma who underwent FDG-PET scanning before undergoing surgical resection between 1999 and 2005. Patients were classified by histologic grade according to the IASLC/ATS/ERS classification (low, intermediate, or high grade) and by maximum standard uptake value (SUVmax) (low <3.0, high ≥3.0). The cumulative incidence of recurrence (CIR) was used to estimate recurrence probabilities. Patients with high-grade histology had higher risk of recurrence (5-year CIR, 29 % [n = 25]) than those with intermediate-grade (13 % [n = 181]) or low-grade (11 % [n = 16]) histology (p = 0.046). High SUVmax was associated with high-grade histology (p < 0.001) and with increased risk of recurrence compared to low SUVmax (5-year CIR, 21 % [n = 113] vs. 8 % [n = 109]; p = 0.013). Among patients with intermediate-grade histology, those with high SUVmax had higher risk of recurrence than those with low SUVmax (5-year CIR, 19 % [n = 87] vs. 7 % [n = 94]; p = 0.033). SUVmax was associated with recurrence even after adjusting for pathologic stage (p = 0.037). SUVmax on FDG-PET correlates with the IASLC/ATS/ERS classification and can be used to stratify patients with intermediate-grade histology, the predominant histologic subtype, into two prognostic subsets.
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影响因子：
20.4
作者：
Goodgame, Boone;Pillot, Giancarlo A.;Govindan, Ramaswamy
通讯作者：
Govindan, Ramaswamy
影响因子：
2.1
作者：
Sawada, Eiichi;Nambu, Atsushi;Miyata, Kazuyuki
通讯作者：
Miyata, Kazuyuki
影响因子：
2.6
作者：
Shim, Sung Shine;Han, Joungho
通讯作者：
Han, Joungho
DOI：
10.1097/jto.0b013e318206a221
发表时间：
2011-02
期刊：
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
影响因子：
--
作者：
Travis WD;Brambilla E;Noguchi M;Nicholson AG;Geisinger KR;Yatabe Y;Beer DG;Powell CA;Riely GJ;Van Schil PE;Garg K;Austin JH;Asamura H;Rusch VW;Hirsch FR;Scagliotti G;Mitsudomi T;Huber RM;Ishikawa Y;Jett J;Sanchez-Cespedes M;Sculier JP;Takahashi T;Tsuboi M;Vansteenkiste J;Wistuba I;Yang PC;Aberle D;Brambilla C;Flieder D;Franklin W;Gazdar A;Gould M;Hasleton P;Henderson D;Johnson B;Johnson D;Kerr K;Kuriyama K;Lee JS;Miller VA;Petersen I;Roggli V;Rosell R;Saijo N;Thunnissen E;Tsao M;Yankelewitz D
通讯作者：
Yankelewitz D
影响因子：
20.4
作者：
Goldstraw, Peter;Crowley, John;Sobin, Leslie
通讯作者：
Sobin, Leslie