Erythrogenic toxins A, B and C: occurrence of the genes and exotoxin formation from clinical Streptococcus pyogenes strains associated with streptococcal toxic shock-like syndrome.
Erythrogenic toxins A, B and C: occurrence of the genes and exotoxin formation from clinical Streptococcus pyogenes strains associated with streptococcal toxic shock-like syndrome.
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红原性毒素 A、B 和 C：与链球菌中毒性休克样综合征相关的临床化脓性链球菌菌株的基因发生和外毒素形成。
DOI：
10.1111/j.1574-6968.1992.tb14058.x
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发表时间：
1992
影响因子：
2.1
通讯作者：
W. Köhler
中科院分区：
文献类型：
--
作者：
W. Reichardt;H. Müller;J. Alouf;W. Köhler
我们报告了对53株A组链球菌临床分离株的研究，这些菌株都来自链球菌中毒性休克综合征患者。对这些菌株进行了A、B、C型红原性毒素(热原性外毒素)基因的出现和体外产生这些毒素的分析。与报告显示85%的中毒性休克综合征相关分离株含有红原性毒素A基因相反，我们的菌株中只有58.5%含有这种基因。22.6%的分离株检测到红毒素C基因。分别有68.7%和58.3%的菌株产生A和B两种毒素。对于所有A组链球菌，无论临床相关性如何，所有被测试的菌株都检测到红原性毒素B基因。因此，很难确定红原性毒素B在中毒性休克样综合征中的特定作用，因为这种疾病与毒素基因的存在之间没有明确的相关性。我们的结果提示A群链球菌产生的其他致病因子(S)可能以与红原性毒素相似的方式刺激人外周T淋巴细胞，从而解释了以往流行病学遗传学研究中不同的观察结果。
We report the study of 53 clinical isolates of group A streptococci, all from patients with streptococcal toxic shock-like syndrome. The strains were analysed for the occurrence of the genes of erythrogenic toxins (pyrogenic exotoxins) types A, B and C and in vitro production of these toxins. In contrast to reports indicating that 85% of the toxic shock-like syndrome-associated isolates contained the erythrogenic toxin A gene, only 58.5% of our strains harboured this gene. The erythrogenic toxin C gene was detected in 22.6% of the isolates. Erythrogenic toxin A and erythrogenic toxin B were produced by 68.7% and 58.3% of the strains containing either gene. For all group A streptococci, irrespective of clinical association, the erythrogenic toxin B gene was detected in all the isolates tested. Thus, it is difficult to define a specific role for erythrogenic toxin B in toxic shock-like syndrome as there was no clear correlation between this disease and the presence of toxin genes. Our results suggest the existence of other pathogenic factor(s) produced by group A streptococci which may stimulate human peripheral T lymphocytes in a manner similar to that of erythrogenic toxins, thus explaining different observations in previous epidemiological genetic studies.
影响因子：
158.5
作者：
CONE, LA;WOODARD, DR;TOMORY, GS
通讯作者：
TOMORY, GS