Heterogeneity in the muscle satellite cell population.

Heterogeneity in the muscle satellite cell population.
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DOI:
10.1016/j.semcdb.2010.09.003
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发表时间:
2010-10
影响因子:
7.3
通讯作者:
Rando TA
Rando TA
中科院分区:
生物学2区
文献类型:
--
作者:
Biressi S;Rando TA

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卫星细胞是负责骨骼肌再生的成体干细胞,其定位在基底层和纤维肌膜之间。越来越多的证据表明,卫星细胞代表了一个异质的细胞群体,具有不同的胚胎起源和多层次的生化和功能多样性。本文综述了基于跨物种研究的卫星细胞种群的丰富多样性。最终,更完整地描述卫星细胞的异质性对于理解其在肌肉生长、体内平衡、组织修复和衰老方面的功能意义至关重要。
Satellite cells, the adult stem cells responsible for skeletal muscle regeneration, are defined by their location between the basal lamina and the fiber sarcolemma. Increasing evidence suggests that satellite cells represent a heterogeneous population of cells with distinct embryological origin and multiple levels of biochemical and functional diversity. This review focuses on the rich diversity of the satellite cell population based on studies across species. Ultimately, a more complete characterization of the heterogeneity of satellite cells will be essential to understand the functional significance in terms of muscle growth, homeostasis, tissue repair, and aging.
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