Promising Antiviral Activities of Natural Flavonoids against SARS-CoV-2 Targets: Systematic Review.
Promising Antiviral Activities of Natural Flavonoids against SARS-CoV-2 Targets: Systematic Review.
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DOI：
10.3390/ijms222011069
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发表时间：
2021-10-14
影响因子：
5.6
通讯作者：
Chaari A
中科院分区：
文献类型：
--
作者：
Kaul R;Paul P;Kumar S;Büsselberg D;Dwivedi VD;Chaari A
由严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)引起的持续的新冠肺炎大流行在过去两年里成为全球主要的公共卫生问题。尽管开发和注射了多种疫苗，但新毒株的突变和对普遍免疫的挑战已将重点转移到缺乏有效的药物来治疗该病。与SARS冠状病毒、MERS冠状病毒和其他非呼吸道病毒一样，黄酮类化合物在硅胶、体外、体内和最近的临床研究中都取得了成功，因此是一种很有前途的治疗干预措施。这篇综述集中于体外研究的数据，分析了黄酮类化合物对SARS-CoV-2的各种关键靶点的影响，并对其构效关系进行了分析。从27篇主要文献中，研究了69个以上的黄酮类化合物对SARS-CoV-2病毒靶标的作用，从前景看好的3C样蛋白酶(3CLpro)到较少被研究的核衣壳(N)蛋白；最有希望的是槲皮素和杨梅素衍生物、黄芩素、黄芩苷、EGCG和单宁酸。我们进一步回顾了黄酮类化合物抗SARS-CoV-2活性的电子研究前景，并列出了正在进行的涉及富含黄酮类提取物与合成药物或其他多酚联合治疗潜力的临床研究，并对黄酮类化合物抗SARS-CoV-2的未来提出了展望。
The ongoing COVID-19 pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) became a globally leading public health concern over the past two years. Despite the development and administration of multiple vaccines, the mutation of newer strains and challenges to universal immunity has shifted the focus to the lack of efficacious drugs for therapeutic intervention for the disease. As with SARS-CoV, MERS-CoV, and other non-respiratory viruses, flavonoids present themselves as a promising therapeutic intervention given their success in silico, in vitro, in vivo, and more recently, in clinical studies. This review focuses on data from in vitro studies analyzing the effects of flavonoids on various key SARS-CoV-2 targets and presents an analysis of the structure-activity relationships for the same. From 27 primary papers, over 69 flavonoids were investigated for their activities against various SARS-CoV-2 targets, ranging from the promising 3C-like protease (3CLpro) to the less explored nucleocapsid (N) protein; the most promising were quercetin and myricetin derivatives, baicalein, baicalin, EGCG, and tannic acid. We further review promising in silico studies featuring activities of flavonoids against SARS-CoV-2 and list ongoing clinical studies involving the therapeutic potential of flavonoid-rich extracts in combination with synthetic drugs or other polyphenols and suggest prospects for the future of flavonoids against SARS-CoV-2.
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影响因子：
5.2
作者：
Al-Ishaq RK;Liskova A;Kubatka P;Büsselberg D
通讯作者：
Büsselberg D
DOI：
10.3390/ph13120447
发表时间：
2020-12-08
期刊：
Pharmaceuticals (Basel, Switzerland)
影响因子：
--
作者：
Al Adem K;Shanti A;Stefanini C;Lee S
通讯作者：
Lee S
影响因子：
5.4
作者：
Arndt, Ariel L.;Larson, Blake J.;Hogue, Brenda G.
通讯作者：
Hogue, Brenda G.
影响因子：
2.5
作者：
Bachmetov, L.;Gal-Tanamy, M.;Zemel, R.
通讯作者：
Zemel, R.
影响因子：
3.1
作者：
Chiow KH;Phoon MC;Putti T;Tan BK;Chow VT
通讯作者：
Chow VT