An Implantable Peripheral Nerve Recording and Stimulation System for Experiments on Freely Moving Animal Subjects.
An Implantable Peripheral Nerve Recording and Stimulation System for Experiments on Freely Moving Animal Subjects.
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DOI：
10.1038/s41598-018-24465-1
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发表时间：
2018-04-17
影响因子：
4.6
通讯作者：
Ghovanloo M
中科院分区：
文献类型：
--
作者：
Lee B;Koripalli MK;Jia Y;Acosta J;Sendi MSE;Choi Y;Ghovanloo M
一项新的研究以大鼠坐骨神经模型为外周神经接口，使用完全植入的感应供电记录和刺激系统，在无线供电的标准家庭中，允许动物受试者在家庭内自由移动。无线植入式神经记录和刺激(WINERS)系统在3 × 1.5 × 0.5 厘米3封装中提供32通道周围神经记录和4通道电流控制刺激功能。窄带下行链路采用近场开关键控脉冲位置调制方式，宽带上行链路采用433 MHz脉冲位置调制方式建立双向数据链路。采用商用软件无线电(SDR)设计了一种外部宽带接收机，用于在PC机上进行稳健的宽带数据采集。Winers-8原型在电池供电的前台和无线供电的植入物两种形式下进行了体内验证，并与商业系统进行了比较。在动物研究中，记录诱发的复合动作电位，以验证Winers-8系统对清醒自由行为大鼠坐骨神经的刺激和记录能力。与传统的电池供电系统相比，Winers可以用于长时间的闭环记录和刺激实验，而不会增加动物受试者携带电池的负担，也不会中断实验。
A new study with rat sciatic nerve model for peripheral nerve interfacing is presented using a fully-implanted inductively-powered recording and stimulation system in a wirelessly-powered standard homecage that allows animal subjects move freely within the homecage. The Wireless Implantable Neural Recording and Stimulation (WINeRS) system offers 32-channel peripheral nerve recording and 4-channel current-controlled stimulation capabilities in a 3 × 1.5 × 0.5 cm3 package. A bi-directional data link is established by on-off keying pulse-position modulation (OOK-PPM) in near field for narrow-band downlink and 433 MHz OOK for wideband uplink. An external wideband receiver is designed by adopting a commercial software defined radio (SDR) for a robust wideband data acquisition on a PC. The WINeRS-8 prototypes in two forms of battery-powered headstage and wirelessly-powered implant are validated in vivo, and compared with a commercial system. In the animal study, evoked compound action potentials were recorded to verify the stimulation and recording capabilities of the WINeRS-8 system with 32-ch penetrating and 4-ch cuff electrodes on the sciatic nerve of awake freely-behaving rats. Compared to the conventional battery-powered system, WINeRS can be used in closed-loop recording and stimulation experiments over extended periods without adding the burden of carrying batteries on the animal subject or interrupting the experiment.
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影响因子：
4.3
作者：
Lee, Byunghun;Kiani, Mehdi;Ghovanloo, Maysam
通讯作者：
Ghovanloo, Maysam
DOI：
10.1109/jestpe.2015.2436391
发表时间：
2016-03
影响因子：
5.5
作者：
Lee B;Ahn D;Ghovanloo M
通讯作者：
Ghovanloo M
DOI：
10.1109/tbcas.2011.2158431
发表时间：
2011-07-14
影响因子：
5.1
作者：
Kiani M;Jow UM;Ghovanloo M
通讯作者：
Ghovanloo M
DOI：
10.1073/pnas.1316885110
发表时间：
2013-12-24
影响因子：
11.1
作者：
Guggenmos, David J.;Azin, Meysam;Nudo, Randolph J.
通讯作者：
Nudo, Randolph J.
影响因子：
4
作者：
Aravanis, Alexander M.;Wang, Li-Ping;Deisseroth, Karl
通讯作者：
Deisseroth, Karl