Genetic association and single-cell transcriptome analyses reveal distinct features connecting autoimmunity with cancers.
Genetic association and single-cell transcriptome analyses reveal distinct features connecting autoimmunity with cancers.
复制标题
DOI：
10.1016/j.isci.2022.104631
复制
发表时间：
2022-07-15
期刊：
影响因子：
5.8
通讯作者：
Mao, Fengbiao
中科院分区：
文献类型：
--
作者：
Li, Shasha;Lu, Chenyang;Zhang, Yuan;Zhao, Xiaolu;Lin, Kequan;Kong, Xiufang;Fox, David;Xue, Lixiang;Sun, Lichao;Liu, Yi;Mao, Fengbiao
自身免疫性疾病（ADs）发生癌症的风险较高，但机制尚不清楚。通过检索GWAS目录数据库和Medline，收集系统性红斑狼疮（SLE）、类风湿性关节炎、Sjögren综合征、系统性硬化症、特发性炎性肌病等5种常见ad的易感基因，并与癌症驱动基因进行重叠分析。单细胞转录组分析比较SLE和相关癌症。我们鉴定出45个致癌自身免疫性疾病风险（CAD）基因，主要富集于T细胞信号通路和B细胞信号通路。综合单细胞分析显示，与SLE相比，免疫细胞信号在肾癌中显著下调，而在肾癌或淋巴瘤和SLE的特定亚群中，干细胞信号显著增强。针对CAD基因的药物在ad和癌症之间是共享的。我们的研究强调了ad和相关癌症之间的共同和特定特征，并揭示了一种新的治疗方法。自身免疫性疾病（AD）与癌症共享风险基因免疫监视和细胞干细胞不平衡可能导致AD发生癌变针对致癌性AD风险基因具有治疗两种实体的潜力；复杂系统生物学；系统生物学;癌症系统生物学
Autoimmune diseases (ADs) are at a significantly higher risk of cancers with unclear mechanism. By searching GWAS catalog database and Medline, susceptible genes for five common ADs, including systemic lupus erythematosus (SLE), rheumatoid arthritis, Sjögren syndrome, systemic sclerosis, and idiopathic inflammatory myopathies, were collected and then were overlapped with cancer driver genes. Single-cell transcriptome analysis was performed in the comparation between SLE and related cancer. We identified 45 carcinogenic autoimmune disease risk (CAD) genes, which were mainly enriched in T cell signaling pathway and B cell signaling pathway. Integrated single-cell analysis revealed immune cell signaling was significantly downregulated in renal cancer compared with SLE, while stemness signature was significantly enriched in both renal cancer or lymphoma and SLE in specific subpopulations. Drugs targeting CAD genes were shared between ADs and cancer. Our study highlights the common and specific features between ADs and related cancers, and sheds light on a new discovery of treatments. Autoimmune diseases (ADs) share risk genes with cancer Imbalance of immunosurveillance and cell stemness may cause cancer development in AD Targeting carcinogenic AD risk genes have the potential in treatment of both entities Bioinformatics; Complex system biology; Systems biology; Cancer systems biology
登录
查看更多内容
基于生物信息学分析的类风湿关节炎和骨关节炎基因特征筛选
影响因子：
3.4
作者：
He P;Zhang Z;Liao W;Xu D;Fu M;Kang Y
通讯作者：
Kang Y
影响因子：
4.7
作者：
Kuksin CA;Minter LM
通讯作者：
Minter LM
影响因子：
64.8
作者：
Cao, Junyue;Spielmann, Malte;Shendure, Jay
通讯作者：
Shendure, Jay
影响因子：
14.9
作者：
Kuleshov MV;Jones MR;Rouillard AD;Fernandez NF;Duan Q;Wang Z;Koplev S;Jenkins SL;Jagodnik KM;Lachmann A;McDermott MG;Monteiro CD;Gundersen GW;Ma'ayan A
通讯作者：
Ma'ayan A
影响因子：
12.3
作者：
Cho A;Shim JE;Kim E;Supek F;Lehner B;Lee I
通讯作者：
Lee I