Salinomycin as a potent anticancer stem cell agent: State of the art and future directions.
Salinomycin as a potent anticancer stem cell agent: State of the art and future directions.
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盐霉素作为有效的抗癌干细胞剂：艺术状态和未来的方向。
DOI：
10.1002/med.21870
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发表时间：
2022-05
影响因子：
13.3
通讯作者：
中科院分区：
文献类型：
--
作者：
癌症干细胞（CSC）是肿瘤内的一小部分细胞亚群，它们可以自我更新并分化为形成异质肿瘤块的其他细胞类型。由于CSC参与癌症发展的所有方面，包括肿瘤起始、细胞增殖、转移性传播、治疗抗性和复发，因此它们已成为癌症治疗和管理的有吸引力的靶标。盐霉素是家禽养殖中广泛使用的抗生素，温伯格小组于2009年将其确定为有效的抗CSC药物。作为聚醚离子载体，盐霉素具有广谱活性，包括重要的抗CSC功能。从那时起，盐霉素抗癌作用机制的研究不断迅速发表。因此，我们必须更新其在这一领域的最新研究成果的文献。本文总结了盐霉素的抗癌活性、细胞内结合靶点、对肿瘤微环境的影响、安全性、衍生物和肿瘤特异性给药等方面的研究成果，并基于目前多方面的认识，探讨了盐霉素在临床应用中的转化潜力。
Cancer stem cells (CSCs) are a small subpopulation of cells within a tumor that can both self‐renew and differentiate into other cell types forming the heterogeneous tumor bulk. Since CSCs are involved in all aspects of cancer development, including tumor initiation, cell proliferation, metastatic dissemination, therapy resistance, and recurrence, they have emerged as attractive targets for cancer treatment and management. Salinomycin, a widely used antibiotic in poultry farming, was identified by the Weinberg group as a potent anti‐CSC agent in 2009. As a polyether ionophore, salinomycin exerts broad‐spectrum activities, including the important anti‐CSC function. Studies on the mechanism of action of salinomycin against cancer have been continuously and rapidly published since then. Thus, it is imperative for us to update its literature of recent research findings in this area. We here summarize the notable work reported on salinomycin's anticancer activities, intracellular binding target(s), effects on tumor microenvironment, safety, derivatives, and tumor‐specific drug delivery; after that we also discuss the translational potential of salinomycin toward clinical application based on current multifaceted understandings.
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DOI：
10.3390/molecules191219435
发表时间：
2014-11-25
期刊：
Molecules (Basel, Switzerland)
影响因子：
--
作者：
Antoszczak M;Maj E;Napiórkowska A;Stefańska J;Augustynowicz-Kopeć E;Wietrzyk J;Janczak J;Brzezinski B;Huczyński A
通讯作者：
Huczyński A
影响因子：
3.7
作者：
An H;Kim JY;Oh E;Lee N;Cho Y;Seo JH
通讯作者：
Seo JH
DOI：
10.2174/1871520615666150101130209
发表时间：
2015-01-01
影响因子：
2.8
作者：
Antoszczak, Michal;Huczynski, Adam
通讯作者：
Huczynski, Adam
影响因子：
6.7
作者：
Antoszczak, Michal;Urbaniak, Alicja;Strand, Daniel
通讯作者：
Strand, Daniel
影响因子：
6.7
作者：
Antoszczak, Michal;Steverding, Dietmar;Huczynski, Adam
通讯作者：
Huczynski, Adam