Ethnic differences in associations between fat deposition and incident diabetes and underlying mechanisms: the SABRE study.
Ethnic differences in associations between fat deposition and incident diabetes and underlying mechanisms: the SABRE study.
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DOI：
10.1002/oby.20997
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发表时间：
2015-03
期刊：
影响因子：
6.9
通讯作者：
Chaturvedi, Nishi
中科院分区：
文献类型：
--
作者：
Eastwood, Sophie V.;Tillin, Therese;Dehbi, Hakim-Moulay;Wright, Andrew;Forouhi, Nita G.;Godsland, Ian;Whincup, Peter;Sattar, Naveed;Hughes, Alun D.;Chaturvedi, Nishi
研究异位脂肪的种族差异及其与糖尿病发病的关系。在一项英国队列研究中，1338名欧洲人、838名南亚人和330名非洲加勒比人生活在伦敦，基线年龄为40-69岁。基线评估包括血液检查、人体测量和问卷调查。基于人体测量学的预测方程估计基线内脏脂肪组织（VAT）。通过记录回顾、自我报告或口服葡萄糖耐量试验确定糖尿病事件。与欧洲人相比，南亚人有更多的增值税，非洲加勒比人有更少的增值税。两个少数民族的躯干皮褶都比欧洲人大。对于男性，调整风险因素（BMI、吸烟、收缩压和HDL-胆固醇）显著减弱了欧洲人估计的VAT和糖尿病之间的关联（标准化亚风险比[95% CI]：从1.74 [1.49，2.03]至1.16 [0.77，1.76]）和非洲加勒比人（1.72 [1.26，2.35]至1.44 [0.69，3.02]），但不是南亚人（1.60 [1.38，1.86]至1.90 [1.37，2.64]）。在女性中，仅在南亚人中观察到衰减（1.80 [1.01，3.23]至1.07 [0.49，2.31]）。与欧洲人相比，南亚人和非洲加勒比人的躯干皮褶和糖尿病之间的关联似乎受多变量调整的影响较小（男性1.24 [0.97，1.57]和1.28 [0.89，1.82]对1.02 [0.77，1.36];女性1.91 [1.03，3.56]和1.42 [0.86，2.34]对1.23 [0.74，2.05]）。躯干脂肪总量和VAT的差异可能导致南亚和非洲加勒比地区人群的糖尿病发病率过高，尤其是女性。
To examine ethnic differences in ectopic fat and associations with incident diabetes. In a UK cohort study, 1338 Europeans, 838 South Asians, and 330 African Caribbeans living in London were aged 40-69 years at baseline. Baseline assessment included blood tests, anthropometry, and questionnaires. Anthropometry-based prediction equations estimated baseline visceral adipose tissue (VAT). Incident diabetes was ascertained from record review, self-report, or oral glucose tolerance testing. South Asians had more and African Caribbeans less estimated VAT than Europeans. Both ethnic minorities had larger truncal skinfolds than Europeans. In men, adjustment for risk factors (BMI, smoking, systolic blood pressure, and HDL-cholesterol) markedly attenuated the association between estimated VAT and diabetes in Europeans (standardized subhazard ratios [95% CI]: from 1.74 [1.49, 2.03] to 1.16 [0.77, 1.76]) and African Caribbeans (1.72 [1.26, 2.35] to 1.44 [0.69, 3.02]) but not South Asians (1.60 [1.38, 1.86] to 1.90 [1.37, 2.64]). In women, attenuation was observed only for South Asians (1.80 [1.01, 3.23] to 1.07 [0.49, 2.31]). Associations between truncal skinfolds and diabetes appeared less affected by multivariable adjustment in South Asians and African Caribbeans than Europeans (1.24 [0.97, 1.57] and 1.28 [0.89, 1.82] versus 1.02 [0.77, 1.36] in men; 1.91 [1.03, 3.56] and 1.42 [0.86, 2.34] versus 1.23 [0.74, 2.05] in women). Differences in overall truncal fat, as well as VAT, may contribute to the excess of diabetes in South Asian and African Caribbean groups, particularly for women.
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影响因子：
8.2
作者：
Hanley, A. J. G.;Wagenknecht, L. E.;Norris, J. M.;Bryer-Ash, M.;Chen, Y. I.;Anderson, A. M.;Bergman, R.;Haffner, S. M.
通讯作者：
Haffner, S. M.
影响因子：
16.2
作者：
Hu G;Bouchard C;Bray GA;Greenway FL;Johnson WD;Newton RL Jr;Ravussin E;Ryan DH;Katzmarzyk PT
通讯作者：
Katzmarzyk PT
影响因子：
16.2
作者：
Boyko, EJ;Fujimoto, WY;Newell-Morris, L
通讯作者：
Newell-Morris, L
影响因子：
120.7
作者：
Brancati, FL;Kao, WHL;Szklo, M
通讯作者：
Szklo, M
影响因子：
8
作者：
Kimm, SYS;Barton, BA;Daniels, SR
通讯作者：
Daniels, SR