Non-absorbable antibiotic treatment inhibits colorectal cancer liver metastasis by modulating deoxycholic acid metabolism by intestinal microbes.
Non-absorbable antibiotic treatment inhibits colorectal cancer liver metastasis by modulating deoxycholic acid metabolism by intestinal microbes.
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不可吸收抗生素治疗通过调节肠道微生物脱氧胆酸代谢抑制结直肠癌肝转移
DOI：
10.7150/jca.63490
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发表时间：
2022
影响因子：
3.9
通讯作者：
Ma J
中科院分区：
文献类型：
--
作者：
Deng J;Yuan W;Tan Q;Wei X;Ma J
新的证据表明，肠道微生物影响结直肠癌（CRC）的发生和发展。然而，很少有研究探讨肠道细菌与结直肠癌肝转移之间的关系。在这项研究中，我们发现，与对照组相比，非吸收性抗生素在小鼠模型中抑制了CRC的肝转移。为了阐明潜在的机制，进行免疫细胞浸润分析、16 S rRNA测序和代谢组学。差异分析显示，非吸收性抗生素治疗显著改变了肠道微生物多样性，并降低了粪便和肝组织中脱氧胆酸（DCA）的浓度。此外，我们证实，在接受不可吸收抗生素治疗的小鼠中，能够通过7α-脱羟基将胆酸（CA）转化为DCA的细菌减少。最后，体外和体内实验证实，DCA促进CRC细胞的增殖和转移。
Emerging evidence suggests that intestinal microbes influence the occurrence and development of colorectal cancer (CRC). However, few studies have examined the relationship between gut bacteria and liver metastasis of CRC. In this study, we found that administration of non-absorbable antibiotics inhibited liver metastasis of CRC in a mouse model compared with a control group. To elucidate the underlying mechanism, immune cell infiltration analysis, 16S rRNA sequencing, and metabolomics were performed. Differential analysis revealed that non-absorbable antibiotic treatment significantly altered gut microbial diversity and decreased the concentration of deoxycholic acid (DCA) in feces and liver tissues. Furthermore, we verified that bacteria capable of converting cholic acid (CA) to DCA via 7α-dehydroxylation were reduced in mice treated with non-absorbable antibiotics. Finally, in vitro and in vivo experiments confirmed that DCA accelerated the proliferation and metastasis of CRC cells.
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影响因子：
4.2
作者：
Hinnebusch, BF;Meng, SF;Hodin, RA
通讯作者：
Hodin, RA
具核梭杆菌通过调节KRT7-AS/KRT7促进结直肠癌转移
影响因子：
12.2
作者：
Chen, Shujie;Su, Tingting;Wang, Liangjing
通讯作者：
Wang, Liangjing
影响因子：
6.1
作者：
Hu, ZP;Tawa, R;Takada, K
通讯作者：
Takada, K
影响因子：
5.6
作者：
Mármol I;Sánchez-de-Diego C;Pradilla Dieste A;Cerrada E;Rodriguez Yoldi MJ
通讯作者：
Rodriguez Yoldi MJ
影响因子：
30.3
作者：
Ivanov II;Honda K
通讯作者：
Honda K