Intestinal commensal microbes as immune modulators.
Intestinal commensal microbes as immune modulators.
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DOI：
10.1016/j.chom.2012.09.009
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发表时间：
2012-10-18
影响因子：
30.3
通讯作者：
Honda K
中科院分区：
文献类型：
--
作者：
Ivanov II;Honda K
共生细菌是发展和维持健康免疫系统所必需的。利用微生物群影响宿主免疫的能力被认为是许多粘膜和非粘膜免疫相关病症的重要治疗策略，例如炎症性肠病（IBD）、乳糜泻、代谢综合征、糖尿病和微生物感染。除了微生物群的明确的免疫刺激作用之外，还描述了具有免疫调节作用的个体互利共生细菌的存在。这些生物体是肠道微生物群的永久成员，并以特定方式影响宿主免疫稳态。识别这种免疫调节剂的个体实例并理解其与宿主相互作用的机制将在设计治疗策略以逆转肠道生态失调和恢复免疫稳态方面是非常宝贵的。
Commensal bacteria are necessary for the development and maintenance of a healthy immune system. Harnessing the ability of microbiota to affect host immunity is considered an important therapeutic strategy for many mucosal and non-mucosal immune-related conditions, such as inflammatory bowel diseases (IBD), celiac disease, metabolic syndrome, diabetes and microbial infections. In addition to well-established immunostimulatory effects of the microbiota, the presence of individual mutualistic commensal bacteria with immunomodulatory effects has been described. These organisms are permanent members of the commensal microbiota and affect host immune homeostasis in specific ways. Identification of individual examples of such immunomodulatory commensals and understanding their mechanisms of interaction with the host will be invaluable in designing therapeutic strategies to reverse intestinal dysbiosis and recover immunological homeostasis.
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影响因子：
6.4
作者：
Heczko, U;Abe, A;Finlay, BB
通讯作者：
Finlay, BB
影响因子：
30.5
作者：
通讯作者：
--
ACE2将氨基酸营养不良与微生物生态学和肠炎联系起来。
影响因子：
64.8
作者：
Hashimoto T;Perlot T;Rehman A;Trichereau J;Ishiguro H;Paolino M;Sigl V;Hanada T;Hanada R;Lipinski S;Wild B;Camargo SM;Singer D;Richter A;Kuba K;Fukamizu A;Schreiber S;Clevers H;Verrey F;Rosenstiel P;Penninger JM
通讯作者：
Penninger JM
影响因子：
64.8
作者：
Devkota, Suzanne;Wang, Yunwei;Musch, Mark W.;Leone, Vanessa;Fehlner-Peach, Hannah;Nadimpalli, Anuradha;Antonopoulos, Dionysios A.;Jabri, Bana;Chang, Eugene B.
通讯作者：
Chang, Eugene B.
DOI：
10.1126/science.1198469
发表时间：
2011-01-21
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Atarashi K;Tanoue T;Shima T;Imaoka A;Kuwahara T;Momose Y;Cheng G;Yamasaki S;Saito T;Ohba Y;Taniguchi T;Takeda K;Hori S;Ivanov II;Umesaki Y;Itoh K;Honda K
通讯作者：
Honda K