Is biological aging accelerated in drug addiction?

Is biological aging accelerated in drug addiction?
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DOI:
10.1016/j.cobeha.2016.09.007
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发表时间:
2017-02
影响因子:
5
通讯作者:
Alia-Klein N
Alia-Klein N
中科院分区:
心理学2区
文献类型:
--
作者:
Bachi K;Sierra S;Volkow ND;Goldstein RZ;Alia-Klein N

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由于药物引起的多系统毒性和危险的生活方式,药物成瘾可能引发年龄相关疾病的早期发作,而这些疾病大多未被发现和治疗。我们介绍了可能加速衰老及其与成瘾相关的病理生理过程的文献,包括:氧化应激和细胞老化,外周和大脑炎症,脑容量和功能下降,以及心、脑血管、肾脏和肝脏疾病的早期发作。及时发现成瘾加速衰老对于预防过早发病和死亡至关重要。
Drug-addiction may trigger early onset of age-related disease, due to drug-induced multi-system toxicity and perilous lifestyle, which remains mostly undetected and untreated. We present the literature on pathophysiological processes that may hasten aging and its relevance to addiction, including: oxidative stress and cellular aging, inflammation in periphery and brain, decline in brain volume and function, and early onset of cardiac, cerebrovascular, kidney, and liver disease. Timely detection of accelerated aging in addiction is crucial for the prevention of premature morbidity and mortality.
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