Immune system inflammation in cocaine dependent individuals: implications for medications development.
Immune system inflammation in cocaine dependent individuals: implications for medications development.
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DOI：
10.1002/hup.1251
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发表时间：
2012-03
影响因子：
1.7
通讯作者：
Sinha, Rajita
中科院分区：
文献类型：
--
作者：
Fox, Helen C.;D'Sa, Carrol;Kimmerling, Anne;Siedlarz, Kristen M.;Tuit, Keri L.;Stowe, Raymond;Sinha, Rajita
可卡因依赖是一种慢性应激状态。此外，压力和药物滥用对免疫系统细胞因子都有强大的相互作用，而免疫系统细胞因子是情绪的强大调节剂。因此，我们研究了可卡因依赖个体中周围细胞因子的基础和诱发变化，以更好地了解它们在可卡因负强化效应中的作用。28名（16 F/12 M）寻求治疗的可卡因依赖者和27名（14 F/13 M）社交饮酒者连续几天随机暴露于三种5分钟引导图像条件（压力、药物提示、放松）。在基线和成像后的各个时间点收集唾液皮质醇、肿瘤坏死因子α (TNFα)、白细胞介素-10 （IL-10）和白细胞介素-1受体拮抗剂（IL-1ra）的测量。与社交饮酒者相比，可卡因滥用者表现出基础IL-10的降低。当他们暴露在压力下时，他们的促炎TNFα也比暴露在放松图像下时显著升高。这在社交饮酒者中没有观察到。相反，社交饮酒者在接触线索后显示出抗炎标志物IL-10和IL-1ra的增加，这在依赖者身上没有发现。可卡因依赖个体在应激意象条件下的基线和暴露后均表现出炎症状态升高。细胞因子可能在成瘾人群中反映潜在的新的生物标志物，用于治疗发展。
Cocaine dependence is a chronic stress state. Furthermore, both stress and substance abuse have robust and reciprocal effects on immune system cytokines, which are known to be powerful modulators of mood. We therefore examine basal and provoked changes in peripheral cytokines in cocaine dependent individuals to better understand their role in the negative reinforcing effects of cocaine. Twenty-eight (16 F/12 M) treatment-seeking cocaine dependent individuals and 27 (14 F/13 M) social drinkers were exposed to three 5-min guided imagery conditions (stress, drug cue, relaxing) presented randomly across consecutive days. Measures of salivary cortisol, tumor necrosis factor alpha (TNFα), interleukin-10 (IL-10), and interleukin-1 receptor antagonist (IL-1ra) were collected at baseline and various post-imagery time-points. Cocaine abusers demonstrated decreased basal IL-10 compared with social drinkers. They also showed significant elevations in pro-inflammatory TNFα when exposed to stress compared with when they were exposed to relaxing imagery. This was not observed in the social drinkers. Conversely, social drinkers demonstrated increases in the anti-inflammatory markers, IL-10 and IL-1ra, following exposure to cue, which were not seen in the dependent individuals. Cocaine dependent individuals demonstrate an elevated inflammatory state both at baseline and following exposure to the stress imagery condition. Cytokines may reflect potentially novel biomarkers in addicted populations for treatment development.
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DOI：
10.1097/01.alc.0000153544.83656.3c
发表时间：
2005-02-01
影响因子：
3.2
作者：
Breese, GR;Chu, K;Weiss, F
通讯作者：
Weiss, F
影响因子：
13.5
作者：
Breese, George R.;Sinha, Rajita;Heilig, Markus
通讯作者：
Heilig, Markus
DOI：
10.1196/annals.1351.006
发表时间：
2006-01-01
期刊：
BASIC AND CLINICAL ASPECTS OF NEUROENDOCRINE IMMUNOLOGY IN RHEUMATIC DISEASES
影响因子：
--
作者：
Calcagni, Emanuele;Elenkov, Ilia
通讯作者：
Elenkov, Ilia
影响因子：
3.3
作者：
Anisman, Hymie;Poulter, Michael O.;Hayley, Shawn
通讯作者：
Hayley, Shawn
影响因子：
6.6
作者：
Bonaccorso, S;Maier, SF;Maes, M
通讯作者：
Maes, M