The Alzheimer's disease-8 and Montreal Cognitive Assessment as screening tools for neurocognitive impairment in HIV-infected persons.
The Alzheimer's disease-8 and Montreal Cognitive Assessment as screening tools for neurocognitive impairment in HIV-infected persons.
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DOI：
10.1007/s13365-012-0147-5
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发表时间：
2013-02
影响因子：
3.2
通讯作者：
Ances, Beau M.
中科院分区：
文献类型：
--
作者：
Overton, Edgar Turner;Azad, Tej D.;Parker, Neva;Shaw, Debra Demarco;Frain, Judy;Spitz, Teresa;Westerhaus, Elizabeth;Paul, Robert;Clifford, David B.;Ances, Beau M.
HIV 相关神经认知障碍的诊断非常耗时，并且在繁忙的门诊环境中经常被忽视。需要简短的筛选工具。蒙特利尔认知评估 (MoCA) 和阿尔茨海默病 (AD)-8 已用于治疗神经退行性疾病。我们评估了这些简短筛查工具在艾滋病毒感染者中的敏感性和特异性。 AD-8、MoCA 和正式的神经心理学测试对同一机构的 200 名 HIV 感染者进行了随访。正式神经心理学测试的标准化分数用于定义神经认知障碍。评估 MoCA 和 AD-8 的敏感性和特异性以诊断损伤。神经认知障碍在该队列中非常普遍：根据正式测试，127 人 (64%) 被诊断为神经认知障碍。使用 AD-8 和 MoCA，分别确定 113 名 (57%) 和 101 名 (51%) 人患有神经认知障碍。 MoCA 的敏感性和特异性分别为 63% 和 71%。 AD-8的敏感性和特异性分别为61%和51%。我们的研究结果强调，简短的筛查工具与正式的神经心理学测试相关。然而，这些筛选工具的灵敏度低于预期。尽管如此，鉴于它们易于管理，这些工具可以作为一线帮助识别随后可能需要正式神经心理学测试的个体。
The diagnosis of HIV-associated neurocognitive impairment is time-intensive and often omitted in busy outpatient settings. Brief screening tools are needed. The Montreal Cognitive Assessment (MoCA) and the Alzheimer’s disease (AD)-8 have been used in neurodegenerative disorders. We evaluated the sensitivity and specificity of these brief screening tools in HIV-infected persons. The AD-8, MoCA, and formal neuropsychological testing were administered to 200 HIV-infected patients followed at a single institution. Normalized scores on formal neuropsychological testing were used to define neurocognitive impairment. The sensitivity and specificity of the MoCA and AD-8 were assessed to diagnose impairment. Neurocognitive impairment was highly prevalent in this cohort: 127 persons (64%) were diagnosed with neurocognitive impairment based on formal testing. Using the AD-8 and MoCA, 113 (57%) and 101 (51%) persons were identified with neurocognitive impairment, respectively. The sensitivity and specificity of MoCA were 63% and 71%, respectively. The sensitivity and specificity of AD-8 were 61% and 51%, respectively. Our findings highlight that brief screening tools correlate with formal neuropsychological testing. However, the sensitivities of these screening tools are lower than desired. Nevertheless, given their ease in administration, these tools could assist as a first line for identifying individuals who may subsequently require formal neuropsychological testing.
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影响因子：
3.2
作者：
Heaton, Robert K.;Franklin, Donald R.;Ellis, Ronald J.;McCutchan, J. Allen;Letendre, Scott L.;LeBlanc, Shannon;Corkran, Stephanie H.;Duarte, Nichole A.;Clifford, David B.;Woods, Steven P.;Collier, Ann C.;Marra, Christina M.;Morgello, Susan;Mindt, Monica Rivera;Taylor, Michael J.;Marcotte, Thomas D.;Atkinson, J. Hampton;Wolfson, Tanya;Gelman, Benjamin B.;McArthur, Justin C.;Simpson, David M.;Abramson, Ian;Gamst, Anthony;Fennema-Notestine, Christine;Jernigan, Terry L.;Wong, Joseph;Grant, Igor
通讯作者：
Grant, Igor
影响因子：
9.9
作者：
Galvin, James E.;Roe, Catherine M.;Morris, John C.
通讯作者：
Morris, John C.
影响因子：
4.9
作者：
METZ, CE
通讯作者：
METZ, CE
影响因子：
9.9
作者：
McCutchan, J. A.;Marquie-Beck, J. A.;Grant, I.
通讯作者：
Grant, I.
影响因子：
9.9
作者：
Clifford, DB;McArthur, JC;Marra, CM
通讯作者：
Marra, CM