Frequency-Based Maternal Electrocardiogram Attenuation for Fetal Electrocardiogram Analysis.
Frequency-Based Maternal Electrocardiogram Attenuation for Fetal Electrocardiogram Analysis.
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基于频率的母亲心电图衰减用于胎儿心电图分析。
DOI：
10.1007/s10439-022-02959-4
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发表时间：
2022-07
影响因子：
3.8
通讯作者：
Govindan, Rathinaswamy
中科院分区：
文献类型：
--
作者：
Roshanitabrizi, Pooneh;Krishnan, Anita;Ingbar, Catherine;Salvador, Tyler;Zhang, Anqing;Donofrio, Mary T.;Govindan, Rathinaswamy
胎儿心电图（ECG）波形分析沿着心脏时间间期（CTI）测量对于高危妊娠的管理至关重要。目前，还没有一种系统可以持续准确地测量胎儿ECG。在这项工作中，我们提出了一种新的自动方法来衰减产妇心电图在频域和增强它与可测量的CTI。首先，识别母体ECG和腹部ECG之间的相干分量，并在频域中从后者中减去。然后使用逆傅立叶变换将残差转换到时域以产生胎儿ECG。通过对多个心跳取平均值改进了该过程。两名胎儿心脏病专家对该方法不知情，根据分级系统评估胎儿ECG的质量并测量CTI。我们使用一个合成数据集、一个公共领域可用的人类数据集和37个临床数据集评估了我们的方法和基于时间的方法的胎儿ECG质量。在分析的37个数据集中，我们的方法的平均值（±标准差）等级为3.49 ± 1.22，而自适应干扰消除为2.64 ± 1.26（p值< 0.001），因此表明基于频率的胎儿ECG提取是上级方法，从我们临床医生的角度进行评估。该方法具有在临床环境中使用的潜力。
Fetal electrocardiogram (ECG) waveform analysis along with cardiac time intervals (CTIs) measurements are critical for the management of high-risk pregnancies. Currently, there is no system that can consistently and accurately measure fetal ECG. In this work, we present a new automatic approach to attenuate the maternal ECG in the frequency domain and enhance it with measurable CTIs. First, the coherent components between the maternal ECG and abdominal ECG were identified and subtracted from the latter in the frequency domain. The residual was then converted into the time domain using the inverse Fourier transform to yield the fetal ECG. This process was improved by averaging multiple beats. Two fetal cardiologists, blinded to the method, assessed the quality of fetal ECG based on a grading system and measured the CTIs. We evaluated the fetal ECG quality of our method and time-based methods using one synthetic dataset, one human dataset available in the public domain, and 37 clinical datasets. Among the 37 datasets analyzed, the mean average (± standard deviation) grade was 3.49 ± 1.22 for our method vs. 2.64 ± 1.26 for adaptive interference cancellation (p-value < 0.001), thus showing the frequency-based fetal ECG extraction was the superior method, as assessed from our clinicians’ perspectives. This method has the potential for use in clinical settings.
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影响因子：
1.6
作者：
Arya, Bhawna;Govindan, Rathinaswamy;Donofrio, Mary T.
通讯作者：
Donofrio, Mary T.
影响因子：
3
作者：
Govindan RB;Kota S;Al-Shargabi T;Massaro AN;Chang T;du Plessis A
通讯作者：
du Plessis A
影响因子：
3.2
作者：
Behar, Joachim;Andreotti, Fernando;Clifford, Gari D.
通讯作者：
Clifford, Gari D.
影响因子：
4.6
作者：
PAN, J;TOMPKINS, WJ
通讯作者：
TOMPKINS, WJ
影响因子：
1.7
作者：
Krupa, Abel Jaba Deva;Dhanalakshmi, Samiappan;Kumar, R.
通讯作者：
Kumar, R.