Non-coding RNAs: a key to future personalized molecular therapy?
Non-coding RNAs: a key to future personalized molecular therapy?
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DOI：
10.1186/gm133
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发表时间：
2010-02-18
期刊：
影响因子：
12.3
通讯作者：
Volinia S
中科院分区：
文献类型：
--
作者：
Galasso M;Sana ME;Volinia S
对非编码RNA(NcRNA)的不断发现改变了人类遗传学和分子生物学的格局。在过去的十年中，ncRNAs参与了许多生理细胞过程，并在病理条件下促进了分子的改变。小干扰RNAs、microRNAs、PIWI相关RNAs、小核仁RNAs和转录超保守区等ncRNAs与癌症、心脏病、免疫紊乱以及神经退行性和代谢性疾病密切相关。NcRNAs在基因调控中具有基础作用，鉴于其分子性质，它们既是新兴的治疗靶点，也是创新的干预工具。下一代测序技术(例如Solid或Genome Analyzer)在高通量检测ncRNA方面发挥着重要作用。用于非侵入性诊断的工具现在包括监测体液中ncRNAs的浓度，新的临床机会包括沉默和抑制ncRNAs或其替换和重新激活。在此，我们综述了我们对人类ncRNAs的生物学功能及其临床潜力的理解的最新进展。
Continual discoveries on non-coding RNA (ncRNA) have changed the landscape of human genetics and molecular biology. Over the past ten years it has become clear that ncRNAs are involved in many physiological cellular processes and contribute to molecular alterations in pathological conditions. Several classes of ncRNAs, such as small interfering RNAs, microRNAs, PIWI-associated RNAs, small nucleolar RNAs and transcribed ultra-conserved regions, are implicated in cancer, heart diseases, immune disorders, and neurodegenerative and metabolic diseases. ncRNAs have a fundamental role in gene regulation and, given their molecular nature, they are thus both emerging therapeutic targets and innovative intervention tools. Next-generation sequencing technologies (for example SOLiD or Genome Analyzer) are having a substantial role in the high-throughput detection of ncRNAs. Tools for non-invasive diagnostics now include monitoring body fluid concentrations of ncRNAs, and new clinical opportunities include silencing and inhibition of ncRNAs or their replacement and re-activation. Here we review recent progress on our understanding of the biological functions of human ncRNAs and their clinical potential.
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