Novel Angiogenic Regulators and Anti-Angiogenesis Drugs Targeting Angiogenesis Signaling Pathways: Perspectives for Targeting Angiogenesis in Lung Cancer.
Novel Angiogenic Regulators and Anti-Angiogenesis Drugs Targeting Angiogenesis Signaling Pathways: Perspectives for Targeting Angiogenesis in Lung Cancer.
复制标题
DOI：
10.3389/fonc.2022.842960
复制
发表时间：
2022
影响因子：
4.7
通讯作者：
Li G
中科院分区：
文献类型：
--
作者：
Li Y;Lin M;Wang S;Cao B;Li C;Li G
Lung cancer growth is dependent on angiogenesis. In recent years, angiogenesis inhibitors have attracted more and more attention as potential lung cancer treatments. Current anti-angiogenic drugs targeting VEGF or receptor tyrosine kinases mainly inhibit tumor growth by reducing angiogenesis and blocking the energy supply of lung cancer cells. However, these drugs have limited efficiency, raising concerns about limited scope of action and mechanisms of patient resistance to existing drugs. Therefore, current basic research on angiogenic regulators has focused more on screening carcinogenic/anticancer genes, miRNAs, lncRNAs, proteins and other biomolecules capable of regulating the expression of specific targets in angiogenesis signaling pathways. In addition, new uses for existing drugs and new drug delivery systems have received increasing attention. In our article, we analyze the application status and research hotspots of angiogenesis inhibitors in lung cancer treatment as a reference for subsequent mechanistic research and drug development.
登录
查看更多内容
影响因子：
2.9
作者：
Elkhider, Abdalkhalig;Wang, Bing;Li, Xia
通讯作者：
Li, Xia
影响因子：
4.2
作者：
Buachan, Paiwan;Namsa-Aid, Maneekarn;Tanechpongtamb, Wanlaya
通讯作者：
Tanechpongtamb, Wanlaya
影响因子：
2.8
作者：
Bolas, Gema;de Rezende, Flavia Figueiredo;Calvete, Juan J.
通讯作者：
Calvete, Juan J.
影响因子：
16
作者：
Ciccia A;Elledge SJ
通讯作者：
Elledge SJ
影响因子：
2.6
作者：
Lawicki, Slawomir;Zajkowska, Monika;Szmitkowski, Maciej
通讯作者：
Szmitkowski, Maciej