Loss of SHP-1 phosphatase alters cytokine expression in the mouse hindbrain following cochlear ablation.
Loss of SHP-1 phosphatase alters cytokine expression in the mouse hindbrain following cochlear ablation.
复制标题
耳蜗消融后，SHP-1 磷酸酶的丧失会改变小鼠后脑中细胞因子的表达。
DOI：
10.1016/j.cyto.2004.05.004
复制
发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Lurie,DianaI
中科院分区：
文献类型：
--
作者：
Zhao,Jie;Lurie,DianaI
Inflammatory cytokines in the central nervous system are largely modulated by glial cells and influence neuronal responses to CNS injury. The protein tyrosine phosphatase SHP-1, an intracellular regulator of many cytokine signaling pathways, has been implicated in mediating the activation of glia. There is a direct correlation between abnormally activated microglia and neuron loss within the SHP-1 deficient motheaten (me/me) mouse auditory brainstem after afferent injury. In order to determine whether loss of SHP-1 creates an aberrant cytokine environment driving the abnormal activation of me/me microglia, the expression of interleukin-4 (IL-4), interleukin-10 (IL-10), interleukin-1beta (IL-1β), tumor necrosis factor-alpha (TNF-α), and interferon-gamma (IFN-γ) was examined by enzyme-linked immunosorbent assay (ELISA). Normal uninjured me/me mice showed lower IL-10 but higher IL-1β levels compared to wild-type. Following unilateral cochlear ablation, there is decreased expression of IL-4 and IL-10 in me/me brains compared to wild-type, but IL-1β is significantly increased. These findings indicate that decreases in anti-inflammatory cytokines, in combination with increased expression of the pro-inflammatory cytokine IL-1β, may initiate a robust inflammatory reaction within the me/me brain contributing to the neuronal degeneration in the deafferented me/me auditory brainstem. SHP-1 may therefore play a role in limiting CNS inflammation following injury and disease.
登录
查看更多内容
小鼠出生后听觉发育的关键时期。
DOI：
10.1016/s0165-5876(83)80111-6
发表时间：
1983
影响因子：
1.5
作者：
Webster,DB
通讯作者：
Webster,DB
motheaten 基因对小鼠 B 和 T 淋巴细胞的表型和功能影响。
影响因子：
4.4
作者：
W. Davidson;H. Morse;S. Sharrow;T. Chused
通讯作者：
T. Chused
SHP-1 在 RBL-2H3 肥大细胞中正向调节 c-Jun N 末端激酶和 TNF-α 的产生，但不调节组胺的释放
影响因子：
4.4
作者：
Z. Xie;Juan Zhang;R. Siraganian
通讯作者：
R. Siraganian
影响因子：
17.3
作者：
Shultz, LD;Rajan, TV;Greiner, DL
通讯作者：
Greiner, DL
影响因子：
3.7
作者：
Hayashi M;Sugahara K;Yamamura A;Iida Y
通讯作者：
Iida Y