Nanoreactors based on DNAzyme-functionalized magnetic nanoparticles activated by magnetic field.
Nanoreactors based on DNAzyme-functionalized magnetic nanoparticles activated by magnetic field.
复制标题
基于磁场激活的DNAZyme官能化磁性纳米颗粒的纳米反应器。
DOI：
10.1039/c7nr08581h
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发表时间：
2018-01-18
期刊：
影响因子：
6.7
通讯作者：
Katz E
中科院分区：
文献类型：
--
作者：
Bakshi SF ;Guz N ;Zakharchenko A ;Deng H ;Tumanov AV ;Woodworth CD ;Minko S ;Kolpashchikov DM ;Katz E
一种新的仿生纳米反应器的设计，MaBiDz，提出了基于共聚物刷结合超顺磁性纳米粒子。这种细胞纳米反应器具有两种磁性颗粒，每种磁性颗粒都具有二元脱氧核酶系统的两种组分。在靶mRNA分析物和磁场的存在下，组装纳米反应器以形成由聚合物刷包围的生物区室，其使得二元脱氧核酶的催化功能具有增强的动力学。MaBiDz在这里被证明是用于转移性乳腺癌的靶mRNA生物标志物的快速检测和成像的细胞传感器，并且其功能显示出作为可以下调靶mRNA生物标志物的活性的仿生细胞器扩展的潜力。
A new biomimetic nanoreactor design, MaBiDz, is presented based on a copolymer brush in combination with superparamagnetic nanoparticles. This cellular nanoreactor features two species of magnetic particles, each functionalized with two components of a binary deoxyribozyme system. In the presence of a target mRNA analyte and a magnetic field, the nanoreactor is assembled to form a biocompartment enclosed by the polymeric brush that enables catalytic function of the binary deoxyribozyme with enhanced kinetics. MaBiDz was demonstrated here as a cellular sensor for rapid detection and imaging of a target mRNA biomarker for metastatic breast cancer, and its function shows potential to be expanded as a biomimetic organelle that can downregulate the activity of a target mRNA biomarker.
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影响因子：
3.2
作者：
Gerasimova, Yulia V.;Cornett, Evan;Kolpashchikov, Dmitry M.
通讯作者：
Kolpashchikov, Dmitry M.
影响因子：
3.5
作者：
Bumb A;Brechbiel MW;Choyke PL;Fugger L;Eggeman A;Prabhakaran D;Hutchinson J;Dobson PJ
通讯作者：
Dobson PJ
影响因子：
15
作者：
Bakshi SF;Guz N;Zakharchenko A;Deng H;Tumanov AV;Woodworth CD;Minko S;Kolpashchikov DM;Katz E
通讯作者：
Katz E
影响因子：
4.6
作者：
Lane DD;Su FY;Chiu DY;Srinivasan S;Wilson JT;Ratner DM;Stayton PS;Convertine AJ
通讯作者：
Convertine AJ
影响因子：
3.9
作者：
Dobrunz, Dominik;Toma, Adriana C.;Palivan, Cornelia G.
通讯作者：
Palivan, Cornelia G.