Ictal propagation of high frequency activity is recapitulated in interictal recordings: effective connectivity of epileptogenic networks recorded with intracranial EEG.
Ictal propagation of high frequency activity is recapitulated in interictal recordings: effective connectivity of epileptogenic networks recorded with intracranial EEG.
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在发作记录中概括了高频活性的发射传播：与颅内脑电图记录的癫痫发作网络的有效连通性。
DOI：
10.1016/j.neuroimage.2014.06.078
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发表时间：
2014-11-01
期刊：
影响因子：
5.7
通讯作者：
Crone NE
中科院分区：
文献类型：
--
作者：
Korzeniewska A;Cervenka MC;Jouny CC;Perilla JR;Harezlak J;Bergey GK;Franaszczuk PJ;Crone NE
人们越来越多地认识到癫痫发作是由致癫痫网络引起的，发作活动在该网络中传播和持续。在接受癫痫手术侵入性监测的患者中，在发作期和发作间期期间，在癫痫发作区内观察到高频振荡。我们假设高频活动传播的模式将有助于阐明致癫痫网络，从而识别与手术计划相关的网络节点。基于格兰杰因果关系的概念，采用多元自回归建模技术（短时直接定向传递函数 - SdDTF）对颅内脑电图记录进行分析，以估计发作期和发作间期记录期间高频活动（70-175 Hz）传播的方向性和强度。这些分析揭示了癫痫学家确定为发作区一部分的高频活动传播的显着分歧和收敛。相比之下，在其他分析站点中观察到这种活动的传播相对较少。这种模式在局灶性发作患者的硬膜下和深度电极记录中都观察到，但在广泛分布的发作患者中没有观察到。在局灶性发作的患者中，发作前（发作前 5 分钟）和发作间期（癫痫发作前后超过 24 小时）间隔期间记录的传播模式与癫痫发作期间记录的传播模式非常相似。从发作间期记录中表征致癫痫网络的能力可能通过减少长时间侵入性监测来记录自发性癫痫发作的需要，从而对癫痫手术计划具有重要的临床意义。
Seizures are increasingly understood to arise from epileptogenic networks across which ictal activity is propagated and sustained. In patients undergoing invasive monitoring for epilepsy surgery, high frequency oscillations have been observed within the seizure onset zone during both ictal and interictal intervals. We hypothesized that the patterns by which high frequency activity is propagated would help elucidate epileptogenic networks and thereby identify network nodes relevant for surgical planning. Intracranial EEG recordings were analyzed with a multivariate autoregressive modeling technique (short-time direct directed transfer function - SdDTF), based on the concept of Granger causality, to estimate the directionality and intensity of propagation of high frequency activity (70–175 Hz) during ictal and interictal recordings. These analyses revealed prominent divergence and convergence of high frequency activity propagation at sites identified by epileptologists as part of the ictal onset zone. In contrast, relatively little propagation of this activity was observed among the other analyzed sites. This pattern was observed in both subdural and depth electrode recordings of patients with focal ictal onset, but not in patients with a widely distributed ictal onset. In patients with focal ictal onsets, the patterns of propagation recorded during pre-ictal (up to 5 minutes immediately preceding ictal onset) and interictal (more than 24 hours before and after seizures) intervals were very similar to those recorded during seizures. The ability to characterize epileptogenic networks from interictal recordings could have important clinical implications for epilepsy surgery planning by reducing the need for prolonged invasive monitoring to record spontaneous seizures.
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影响因子：
2.7
作者：
Franaszczuk, PJ;Bergey, GK
通讯作者：
Bergey, GK
影响因子：
6.1
作者：
Derchansky, M.;Rokni, D.;Carlen, P. L.
通讯作者：
Carlen, P. L.
影响因子：
5.7
作者：
Ding, Lei;Worrell, Gregory A.;He, Bin
通讯作者：
He, Bin
影响因子：
1.9
作者：
Ding, MZ;Bressler, SL;Liang, HL
通讯作者：
Liang, HL
影响因子：
--
作者：
Fisher, RA
通讯作者：
Fisher, RA