Serum 25-OH vitamin D levels and risk of developing prostate cancer in older men.
Serum 25-OH vitamin D levels and risk of developing prostate cancer in older men.
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DOI：
10.1007/s10552-010-9557-y
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发表时间：
2010-08
期刊：
影响因子：
--
通讯作者：
Beer TM
中科院分区：
文献类型：
--
作者：
Barnett CM;Nielson CM;Shannon J;Chan JM;Shikany JM;Bauer DC;Hoffman AR;Barrett-Connor E;Orwoll E;Beer TM
多项研究在实验室实验中显示了维生素D对前列腺癌细胞的抗肿瘤作用的明确证据，但在人类中的证据并不一致。我们试图在一组老年男性中研究维生素D与前列腺癌风险之间的关系。我们在多中心男性骨质疏松性骨折（MrOS）研究中进行了一项前瞻性病例队列研究。基线血清25-OH维生素D是在一个随机选择的子队列中测量的，该子队列包括1，433名年龄≥65岁、无前列腺癌病史的男性和所有诊断为前列腺癌的参与者（n = 297）。考克斯比例风险模型用于评估总25-羟基维生素D的四分位数与前列腺癌发病率以及Gleason评分之间的相关性。与25-OH维生素D的最低四分位数相比，25-OH维生素D的最高四分位数的风险比为1.22（CI 0.50-1.72，p = 0.25），未观察到跨四分位数的趋势（p = 0.94）或与Gleason评分的相关性。协变量调整未改变结果。在这个老年男性的前瞻性队列中，我们发现血清25-OH维生素D水平与随后的前列腺癌风险之间没有关联。
Multiple studies have shown clear evidence of vitamin D’s anti-tumor effects on prostate cancer cells in laboratory experiments, but the evidence has not been consistent in humans. We sought to examine the association between vitamin D and prostate cancer risk in a cohort of older men. We conducted a prospective case-cohort study nested within the multicenter Osteoporotic Fractures in Men (MrOS) study. Baseline serum 25-OH vitamin D was measured in a randomly selected sub-cohort of 1,433 men ≥65 years old without a history of prostate cancer and from all participants with an incident diagnosis of prostate cancer (n = 297). Cox proportional hazards models were used to evaluate the associations between quartiles of total 25-OH vitamin D and incident prostate cancer, as well as Gleason score. In comparison with the lowest quartile of 25-OH vitamin D, the hazard ratio for the highest quartile of 25-OH vitamin D was 1.22 (CI 0.50–1.72, p = 0.25), no trend across quartiles (p = 0.94) or association with Gleason score was observed. Adjustment for covariates did not alter the results. In this prospective cohort of older men, we found no association between serum 25-OH vitamin D levels and subsequent risk of prostate cancer.
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影响因子：
2.1
作者：
Getzenberg, RH;Light, BW;Johnson, CS
通讯作者：
Johnson, CS
影响因子：
2.2
作者：
Orwoll, E;Blank, JB;Stone, K
通讯作者：
Stone, K
影响因子：
10.3
作者：
Ahn, Jiyoung;Peters, Ulrike;Hayes, Richard B.
通讯作者：
Hayes, Richard B.
影响因子：
11.2
作者：
John, EM;Schwartz, GG;Ingles, SA
通讯作者：
Ingles, SA
影响因子：
168.9
作者：
Luscombe, CJ;Fryer, AA;Strange, RC
通讯作者：
Strange, RC