Sensitivity-enhanced and noise-reduced surface plasmon resonance sensing with microwell chips
Sensitivity-enhanced and noise-reduced surface plasmon resonance sensing with microwell chips
复制标题
使用微孔芯片进行灵敏度增强和降噪的表面等离子体共振传感
DOI:
10.1088/0957-0233/26/8/085104
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发表时间:
2015-07
影响因子:
2.4
通讯作者:
Xiaoping Wang
中科院分区:
文献类型:
--
作者:
Wei Dong;Bing Zhang;Shuyue Zhan;Xiaoping Wang
In this paper, we study a surface plasmon resonance (SPR) sensor with a microwell chip that is aimed at improving the sensitivity and reducing the noise. We present both theoretical simulations and experimental results obtained for the proposed structure. In comparison to most SPR sensors that use planar gold films, this proposed well structure enables a sensitivity enhancement of 128%. By confining the surface plasmon wave (SPW) within the well, we are able to reduce the noise by more than twice. The increased sensitivity and lower noise makes our proposed novel microwell chip suitable for small molecule or trace amount detection.
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