Hypothalamic interaction with reward-related regions during subjective evaluation of foods
Hypothalamic interaction with reward-related regions during subjective evaluation of foods
复制标题
在对食物进行主观评价时，下丘脑与奖励相关区域的相互作用
DOI：
10.1016/j.neuroimage.2022.119744
复制
发表时间：
2022
期刊：
影响因子：
5.7
通讯作者：
Konishi S
中科院分区：
文献类型：
--
作者：
Ogawa A;Osada T;Tanaka M;Suda A;Nakajima K;Oka S;Kamagata K;Aoki S;Oshima Y;Tanaka S;Hattori N;Konishi S
在中脑、腹侧纹状体、眼眶前额叶皮质和腹内侧额前皮质实施的奖励系统评估和比较给予生物的各种奖励。已有研究表明，自主神经因素通过下丘脑影响奖赏相关的处理，但下丘脑如何调节奖赏系统仍然难以捉摸。在这项功能磁共振成像研究中，下丘脑被分割成独立的下丘脑核团，执行不同的自主神经功能，使用边界映射分割分析。然后，研究了在奖励任务中主观评价食物时，人类下丘脑核团和奖励相关区域之间的有效相互作用。我们发现与货币评价相比，食物评价中下丘脑室旁核(PVH)和外侧核的脑活动显著降低。心理生理交互作用分析显示，PVH与(1)中脑区和(2)腹内侧前额叶皮质之间存在双重交互作用，前者与参与者更强的觅食倾向相关。动态因果模型分析进一步揭示了从PVH到中脑和前额叶腹内侧皮质的单向相互作用。这些结果表明，人类下丘脑的PVH与大脑皮层中与奖赏相关的区域通过多条通路(即中脑通路和腹内侧额前通路)相互作用，以评估后续决策的奖赏。
The reward system implemented in the midbrain, ventral striatum, orbitofrontal cortex, and ventromedial prefrontal cortex evaluates and compares various types of rewards given to the organisms. It has been suggested that autonomic factors influence reward-related processing via the hypothalamus, but how the hypothalamus modulates the reward system remains elusive. In this functional magnetic resonance imaging study, the hypothalamus was parcellated into individual hypothalamic nuclei performing different autonomic functions using boundary mapping parcellation analyses. The effective interaction during subjective evaluation of foods in a reward task was then investigated between the human hypothalamic nuclei and the reward-related regions. We found significant brain activity decrease in the paraventricular nucleus (PVH) and lateral nucleus in the hypothalamus in food evaluation compared with monetary evaluation. A psychophysiological interaction analysis revealed dual interactions between the PVH and (1) midbrain region and (2) ventromedial prefrontal cortex, with the former correlated with the stronger tendency of participants toward food-seeking. A dynamic causal modeling analysis further revealed unidirectional interactions from the PVH to the midbrain and ventromedial prefrontal cortex. These results suggest that the PVH in the human hypothalamus interacts with the reward-related regions in the cerebral cortex via multiple pathways (i.e., the midbrain pathway and ventromedial prefrontal pathway) to evaluate rewards for subsequent decision-making.
登录
查看更多内容
影响因子：
25
作者：
Suzuki S;Cross L;O'Doherty JP
通讯作者：
O'Doherty JP
DOI：
10.1073/pnas.0912838107
发表时间：
2010-03-30
影响因子：
11.1
作者：
Kahnt, Thorsten;Heinzle, Jakob;Haynes, John-Dylan
通讯作者：
Haynes, John-Dylan
影响因子：
2.5
作者：
Minamimoto, Takafumi;La Camera, Giancarlo;Richmond, Barry J.
通讯作者：
Richmond, Barry J.
影响因子：
16.2
作者：
O'Doherty, JP;Buchanan, TW;Dolan, RJ
通讯作者：
Dolan, RJ
影响因子：
3
作者：
Motoki Kosuke;Suzuki Shinsuke
通讯作者：
Suzuki Shinsuke