Elucidating the underlying components of food valuation in the human orbitofrontal cortex.

Elucidating the underlying components of food valuation in the human orbitofrontal cortex.
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DOI:
10.1038/s41593-017-0008-x
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发表时间:
2017-12
影响因子:
25
通讯作者:
O'Doherty JP
O'Doherty JP
中科院分区:
医学1区
文献类型:
--
作者:
Suzuki S;Cross L;O'Doherty JP

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对粮食的估价是我们决策的基本组成部分。然而,人们对大脑如何构建食物和其他奖励的价值信号知之甚少。利用人类参与者的食物为基础的决策任务,我们发现,主观价值可以预测的信念组成的营养属性的食物:蛋白质,脂肪,碳水化合物和维生素含量。功能磁共振成像数据的多变量分析表明,虽然食物的价值是代表在内侧和外侧部分的眶额皮质(OFC)的神经活动模式,只有外侧OFC代表元素的营养属性。有效的连通性分析进一步表明,关于外侧OFC中表示的营养属性的信息被整合在内侧OFC中以计算整体值。这些发现提供了一个机械帐户的建设,从其组成营养素的食物价值。
The valuation of food is a fundamental component of our decision-making. Yet, little is known about how value signals for food and other rewards are constructed by the brain. Utilizing a food-based decision task in human participants, we found that subjective values can be predicted from beliefs about constituent nutritive attributes of food: protein, fat, carbohydrate and vitamin content. Multivariate analyses on fMRI data demonstrated that while food value is represented in patterns of neural activity in both medial and lateral parts of the orbitofrontal cortex (OFC), only the lateral OFC represents the elemental nutritive attributes. Effective connectivity analyses further indicate that information about the nutritive attributes represented in the lateral OFC is integrated within the medial OFC to compute an overall value. These findings provide a mechanistic account for the construction of food-value from its constituent nutrients.
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