Asymmetric spermatocyte division as a mechanism for controlling sex ratios.

Asymmetric spermatocyte division as a mechanism for controlling sex ratios.
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DOI:
10.1038/ncomms1160
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发表时间:
2011-01-18
影响因子:
16.6
通讯作者:
Pires-Dasilva A
Pires-Dasilva A
中科院分区:
综合性期刊1区
文献类型:
--
作者:
Shakes DC;Neva BJ;Huynh H;Chaudhuri J;Pires-Dasilva A

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尽管孟德尔第一定律预测 XY(或 XO)雄性和 XX 雌性之间的杂交应产生相同数量的雄性和雌性,但多种后生动物中的个体传递其性染色体的方式并不均匀,并产生性别比例高度偏差的后代。在这里,我们报告了对精子发生细胞程序的两种修改,这两种修改结合在一起,有助于解释为什么自由生活的线虫物种Rhabditis sp.的雄性会产生这种变化。 SB347 的雄性后代少于 5%。首先,精子发生程序涉及改良的减数分裂,其中未配对的 X 染色体的染色单体在减数分裂 I 中过早分离。其次,在减数分裂 II 期间,精子运动所必需的细胞成分几乎完全分配给带有 X 的精子。我们的研究揭示了携带 X 的精子差异传输的新细胞机制,并表明 R. sp。 SB347 作为研究性染色体驱动和新交配系统进化的有用模型。
Although Mendel's first law predicts that crosses between XY (or XO) males and XX females should yield equal numbers of males and females, individuals in a wide variety of metazoans transmit their sex chromosomes unequally and produce broods with highly skewed sex ratios. Here we report two modifications to the cellular program of spermatogenesis which, in combination, help explain why males of the free-living nematode species Rhabditis sp. SB347 sire less than 5% male progeny. First, the spermatogenesis program involves a modified meiosis in which chromatids of the unpaired X chromosome separate prematurely, in meiosis I. Second, during anaphase II, cellular components essential for sperm motility are partitioned almost exclusively to the X-bearing sperm. Our studies reveal a novel cellular mechanism for the differential transmission of X-bearing sperm and suggest R. sp. SB347 as a useful model for studying sex chromosome drive and the evolution of new mating systems.
DOI: 10.1007/bf00710603
发表时间: 1993-05-01
影响因子: 2.6
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