A sprayable Acid-Oxidizing solution containing hypochlorous acid (AOS2020) efficiently and safely inactivates SARS-Cov-2: a new potential solution for upper respiratory tract hygiene.
A sprayable Acid-Oxidizing solution containing hypochlorous acid (AOS2020) efficiently and safely inactivates SARS-Cov-2: a new potential solution for upper respiratory tract hygiene.
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DOI：
10.1007/s00405-021-06644-5
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发表时间：
2021-08
期刊：
影响因子：
--
通讯作者：
Reiner G
中科院分区：
文献类型：
--
作者：
Giarratana N;Rajan B;Kamala K;Mendenhall M;Reiner G
为了消除COVID-19大流行，需要阻断和/或至少减少SARS-CoV-2病毒在人群中的传播。上呼吸道病毒载量在疾病的早期阶段最高，高载量与较高的死亡率相关。本研究旨在评价一种新型可喷雾的酸氧化溶液AOS 2020（含有纯且稳定的次氯酸（HClO））在体外对人冠状病毒SARS-Cov-2的杀病毒效力，以及鼻和口腔粘膜的耐受性特征，表明其是一种潜在的上呼吸道卫生解决方案。根据相关国家和国际指南和方法进行杀病毒试验以及鼻内和口腔刺激试验。在临床前试验中，AOS 2020在< 1分钟内对SARS-Cov-2显示出> 99.8%的杀病毒效力。鼻粘膜和口腔粘膜的安全性特征试验表明，AOS 2020无刺激性。这些初步结果表明，本品具有降低上呼吸道病毒载量的潜在治疗作用。
To eliminate the COVID-19 pandemic, the transmission of the virus SARS-CoV-2 among the population needs to be blocked and/or at least reduced. Upper respiratory tract viral loads are highest in the early stages of the disease, and high loads are associated with higher mortality rates. This study aims to evaluate the virucidal efficacy of AOS2020, a novel sprayable Acid-Oxidizing solution containing pure and stable hypochlorous acid (HClO), on human coronavirus SARS-Cov-2 in vitro, and the tolerability profile on nasal and oral mucosa suggesting to be a potential solution for upper respiratory hygiene. Virucidal assays and intranasal and oral irritation tests were undertaken in accordance with relevant national and international guidance and methods. In pre-clinical tests, the AOS2020, showed > 99.8% virucidal efficacy in < 1 min against SARS-Cov-2. The safety profile testing on both the nasal and oral mucosa indicates that AOS2020 is non-irritant. These initial results indicate that this product has the potential treatment to reduce viral load in the upper respiratory tract.
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