Specific Biomarkers Associated With Neurological Complications and Congenital Central Nervous System Abnormalities From Zika Virus-Infected Patients in Brazil.
Specific Biomarkers Associated With Neurological Complications and Congenital Central Nervous System Abnormalities From Zika Virus-Infected Patients in Brazil.
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DOI：
10.1093/infdis/jix261
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发表时间：
2017-07-15
期刊：
影响因子：
--
通讯作者：
Zika-Unicamp Network
中科院分区：
文献类型：
--
作者：
Kam YW;Leite JA;Lum FM;Tan JJL;Lee B;Judice CC;Teixeira DAT;Andreata-Santos R;Vinolo MA;Angerami R;Resende MR;Freitas ARR;Amaral E;Junior RP;Costa ML;Guida JP;Arns CW;Ferreira LCS;Rénia L;Proença-Modena JL;Ng LFP;Costa FTM;Zika-Unicamp Network
首次对寨卡病毒（ZIKV）感染患者的免疫介质进行系统性大规模分析。已经鉴定了几种关键的免疫介质用于控制ZIKV发病机制。这将阐明患者中ZIKV感染的分子机制。寨卡病毒（ZIKV）感染与不同程度的临床结果有关，从轻度皮疹和发烧到严重的神经系统并发症和先天性畸形。我们研究了临床和免疫应答，重点是来自巴西坎皮纳斯的95例急性ZIKV感染成人患者的免疫介质谱。这些患者包括6名后来在本研究期间分娩的孕妇。住院期间记录临床观察结果。使用基于多重微珠的免疫测定定量45种免疫介质的水平。而11.6%的患者有神经系统并发症，88.4%的患者表现为皮疹和发热的轻度疾病。几种免疫介质在ZIKV感染患者中特别高，白细胞介素10，干扰素γ诱导蛋白10（IP-10）和肝细胞生长因子的水平在有或没有神经系统并发症的患者之间存在差异。有趣的是，在携带胎儿生长相关畸形胎儿的ZIKV感染孕妇中观察到较高水平的白细胞介素22，单核细胞趋化蛋白1，TNF-α和IP-10。值得注意的是，患有先天性中枢神经系统畸形的婴儿的白细胞介素18和IP-10水平显着高于ZIKV感染母亲所生的没有此类异常的婴儿，但肝细胞生长因子水平较低。本研究鉴定了用于控制ZIKV发病机制的几个关键标志物。这将允许更好地理解患者中ZIKV感染的分子机制。
The first systematic large-scale analysis of immune mediators reported in patients with Zika virus (ZIKV) infection. Several key immune mediators have been identified for the control of ZIKV pathogenesis. This will clarify the molecular mechanisms of ZIKV infection in patients. Zika virus (ZIKV) infections have been linked to different levels of clinical outcomes, ranging from mild rash and fever to severe neurological complications and congenital malformations. We investigated the clinical and immunological response, focusing on the immune mediators profile in 95 acute ZIKV-infected adult patients from Campinas, Brazil. These patients included 6 pregnant women who later delivered during the course of this study. Clinical observations were recorded during hospitalization. Levels of 45 immune mediators were quantified using multiplex microbead-based immunoassays. Whereas 11.6% of patients had neurological complications, 88.4% displayed mild disease of rash and fever. Several immune mediators were specifically higher in ZIKV-infected patients, and levels of interleukin 10, interferon gamma-induced protein 10 (IP-10), and hepatocyte growth factor differentiated between patients with or without neurological complications. Interestingly, higher levels of interleukin 22, monocyte chemoattractant protein 1, TNF-α, and IP-10 were observed in ZIKV-infected pregnant women carrying fetuses with fetal growth–associated malformations. Notably, infants with congenital central nervous system deformities had significantly higher levels of interleukin 18 and IP-10 but lower levels of hepatocyte growth factor than those without such abnormalities born to ZIKV-infected mothers. This study identified several key markers for the control of ZIKV pathogenesis. This will allow a better understanding of the molecular mechanisms of ZIKV infection in patients.
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影响因子：
5.4
作者：
Li, Fang;Wang, Yueyun;Fu, Zhen F.
通讯作者：
Fu, Zhen F.
尖端：IL-18对NK细胞的启动。
DOI：
10.4049/jimmunol.181.3.1627
发表时间：
2008-08-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Chaix J;Tessmer MS;Hoebe K;Fuséri N;Ryffel B;Dalod M;Alexopoulou L;Beutler B;Brossay L;Vivier E;Walzer T
通讯作者：
Walzer T
DOI：
10.1016/0035-9203(52)90042-4
发表时间：
1952-01-01
影响因子：
2.2
作者：
DICK, GWA;KITCHEN, SF;HADDOW, AJ
通讯作者：
HADDOW, AJ
影响因子：
9.4
作者：
Lustig, Yaniv;Zelena, Hana;Schwartzh, Eli
通讯作者：
Schwartzh, Eli
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影响因子：
24.1
作者：
Liu Q;Zhou YH;Yang ZQ
通讯作者：
Yang ZQ