Time, space, and disorder in the expanding proteome universe.
Time, space, and disorder in the expanding proteome universe.
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扩展的蛋白质组宇宙中的时空和无序。
DOI：
10.1002/pmic.201600399
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发表时间：
2017-04
期刊：
影响因子：
3.4
通讯作者：
Lilley KS
中科院分区：
文献类型：
--
作者：
Minde DP;Dunker AK;Lilley KS
蛋白质是高度动态的实体。传统上，我们一次探索了一个蛋白质，但我们重点介绍了新兴的全球方法，这些方法加速了全面的洞察力，这些方法是整合蛋白质结构的动态性质的这些方面机制。
Proteins are highly dynamic entities. Their myriad functions require specific structures, but proteins’ dynamic nature ranges all the way from the local mobility of their amino acid constituents to mobility within and well beyond single cells. A truly comprehensive view of the dynamic structural proteome includes: (i) alternative sequences, (ii) alternative conformations, (iii) alternative interactions with a range of biomolecules, (iv) cellular localizations, (v) alternative behaviors in different cell types. While these aspects have traditionally been explored one protein at a time, we highlight recently emerging global approaches that accelerate comprehensive insights into these facets of the dynamic nature of protein structure. Computational tools that integrate and expand on multiple orthogonal data types promise to enable the transition from a disjointed list of static snapshots to a structurally explicit understanding of the dynamics of cellular mechanisms.
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影响因子：
56.9
作者：
Choudhary, Chunaram;Kumar, Chanchal;Mann, Matthias
通讯作者：
Mann, Matthias
影响因子：
64.8
作者：
Demarest, SJ;Martinez-Yamout, M;Wright, PE
通讯作者：
Wright, PE
影响因子：
16.6
作者：
Colin PY;Kintses B;Gielen F;Miton CM;Fischer G;Mohamed MF;Hyvönen M;Morgavi DP;Janssen DB;Hollfelder F
通讯作者：
Hollfelder F
影响因子：
64.8
作者：
Chakravarti, D;LaMorte, VJ;Evans, RM
通讯作者：
Evans, RM
DOI：
10.1074/mcp.m111.011429
发表时间：
2012-03
期刊：
Molecular & cellular proteomics : MCP
影响因子：
--
作者：
Boisvert FM;Ahmad Y;Gierliński M;Charrière F;Lamont D;Scott M;Barton G;Lamond AI
通讯作者：
Lamond AI