Regional trends in suspected synthetic cannabinoid exposure from January 2016 to September 2019 in the United States.
Regional trends in suspected synthetic cannabinoid exposure from January 2016 to September 2019 in the United States.
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DOI：
10.1016/j.drugalcdep.2019.107810
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发表时间：
2020-02-01
影响因子：
4.2
通讯作者：
Vivolo-Kantor, Alana M.
中科院分区：
文献类型：
--
作者：
Roehler, Douglas R.;Hoots, Brooke E.;Vivolo-Kantor, Alana M.
合成大麻素（SCs）的生理和药理作用难以预测，并且随着其化学结构的演变不断变化，以避免在美国《受控物质法案》下被归类为一类药物。这导致了不可预测的药理作用和后续后遗症。人们对合成大麻素聚集的全国或地区趋势知之甚少。本研究的目的是利用急诊科（ED）综合征数据来调查合成大麻素暴露的趋势。
我们分析了急诊科综合征数据，以检测2016年1月至2019年9月期间美国各地区47个州59个辖区内与合成大麻素相关暴露的季度趋势。皮尔逊卡方检验检测季度间的变化，连接点回归评估随时间的趋势。
2016年1月至2019年9月，在3.035亿次急诊科就诊中，有21714次涉及疑似合成大麻素暴露。在全国范围内，与合成大麻素相关的暴露平均每季度下降1.9%（p = 0.04），然而在中西部地区平均每季度增加6.3%（p = 0.002），在东北部地区平均每季度增加3.2%（p = 0.03），在东南部地区平均每季度下降7.7%（p≤0.001），在西部地区平均每季度下降11.4%（p≤0.001）。在季度监测中发现了可能与聚集相关的已知合成大麻素暴露情况。
只有一小部分急诊科就诊与疑似合成大麻素暴露有关。尽管我们确实发现全国合成大麻素暴露量有小幅下降，但地区间差异很大。需要进一步努力了解这种差异，并制定预防和应对策略。
The unpredictable physiologic and pharmacologic effects of synthetic cannabinoids (SCs) are continuously changing as the chemical structure of SCs evolve to avoid classification as a Schedule I drug under the Controlled Substances Act in the U.S. This results in unpredictable pharmacologic effects and subsequent sequelae. Little is known about national or regional trends of SC clusters. The objective of this study is to investigate trends in SC exposure using emergency department (ED) syndromic data. We analyzed ED syndromic data to detect quarterly trends from January 2016 through September 2019 for SC-related exposures within 59 jurisdictions in 47 states by U.S. region. Pearson chi-square tests detected quarter-to-quarter changes and Joinpoint regression assessed trends over time. From January 2016 to September 2019, 21,714 of 303.5 million ED visits involved suspected SC exposures. Nationally, SC-related exposures decreased by 1.9 % (p = .04) on average per quarter, yet exposures increased in the Midwest by 6.3 % (p = .002) and in the Northeast by 3.2 % (p = .03) on average per quarter, and decreased on average per quarter by 7.7% (p ≤ .001) in the Southeast and 11.4 % in the West (p ≤ .001). Known SC exposures that may align with clusters were identified in quarter-to-quarter monitoring. Only a small proportion of ED visits were related to suspected SC exposure. Although we did identify a small decrease in national SC exposures, there was wide variation by region. Additional efforts are needed to understand variation and to develop prevention and response strategies.
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影响因子：
5
作者：
Atwood, Brady K.;Lee, Donghoon;Mackie, Ken
通讯作者：
Mackie, Ken
影响因子：
158.5
作者：
Kelkar, Amar H.;Smith, Nichole A.;Roberts, Jonathan C.
通讯作者：
Roberts, Jonathan C.
影响因子：
3.3
作者：
Richards, Chesley L.;Iademarco, Michael F.;Frieden, Thomas R.
通讯作者：
Frieden, Thomas R.
影响因子：
4.2
作者：
Castaneto, Marisol S.;Gorelick, David A.;Desrosiers, Nathalie A.;Hartman, Rebecca L.;Pirard, Sandrine;Huestis, Marilyn A.
通讯作者：
Huestis, Marilyn A.
影响因子：
3.3
作者：
Gould, Deborah W.;Walker, David;Yoon, Paula W.
通讯作者：
Yoon, Paula W.