Maternal hair cortisol levels as a novel predictor of neonatal abstinence syndrome severity: A pilot feasibility study.
Maternal hair cortisol levels as a novel predictor of neonatal abstinence syndrome severity: A pilot feasibility study.
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母亲头发皮质醇水平作为新生儿戒断综合征严重程度的新预测因子：一项试点可行性研究。
DOI：
10.1002/dev.21896
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发表时间：
2020
影响因子：
2.2
通讯作者：
Tronick,Edward
中科院分区：
文献类型：
--
作者：
Wachman,ElishaM;Hunter,RichardG;Shrestha,Hira;Lapp,HannahE;Meyer,Jerrold;Alvarez,CrystalD;Tronick,Edward
宫内阿片类药物暴露后的新生儿戒断综合征（NAS）仍然是一种知之甚少的疾病，多种因素导致其严重程度。母亲的压力可能是一个促成因素。毛发皮质醇测量代表了一种评估产前压力的新技术。在这项初步研究中，对70名产后阿片类药物使用障碍妇女在分娩后72小时内进行了产妇头发皮质醇水平与NAS严重程度之间的关系研究。对婴儿进行NAS监测，并根据机构方案进行治疗。44名（63%）婴儿接受了NAS药物治疗，所有婴儿的平均住院时间（LOS）为14.2 （SD9.0）天。母亲的平均皮质醇水平为131.8 pg/mg （SD124.7）。在双变量分析中，较高的母亲头发皮质醇水平与较短的婴儿LOS相关（R= -）。26,p= .03)，婴儿阿片类药物治疗天数较少(R= -。28日,p = .02点)。在调整了母体阿片类药物和吸烟因素后，回归模型的结果不再具有统计学意义。总之，我们证明了在阿片类药物使用障碍的母亲分娩后最初几天内进行毛发皮质醇检测作为NAS的新标志物的可行性。研究结果表明，母亲的压力可能影响婴儿阿片类药物戒断的严重程度。
Neonatal abstinence syndrome (NAS) after in‐utero opioid exposure remains a poorly understood condition with multiple factors contributing to severity. Exposure to maternal stress may be one contributing factor. Hair cortisol measurement represents a novel technique for assessing prenatal stress. In this pilot study, the association between maternal hair cortisol levels and NAS severity was examined in 70 postpartum women with opioid use disorder within 72 hr of delivery. Infants were monitored for NAS and treated according to institutional protocol. Forty‐four (63%) of the infants were pharmacologically treated for NAS, with a mean length of hospital stay (LOS) for all infants of 14.2 (SD9.0) days. The mean cortisol level in the mothers was 131.8 pg/mg (SD124.7). In bivariate analysis, higher maternal hair cortisol levels were associated with shorter infant LOS (R= −.26,p= .03) and fewer infant opioid treatment days (R= −.28,p= .02). Results were no longer statistically significant in regression models after adjusting for maternal opioid and smoking. In conclusion, we demonstrated the feasibility of hair cortisol assaying within the first few days after delivery in mothers with opioid use disorder as a novel marker for NAS. The findings suggest that maternal stress may impact the severity of infant opioid withdrawal.
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影响因子：
3.8
作者：
Paquette AG;Lester BM;Lesseur C;Armstrong DA;Guerin DJ;Appleton AA;Marsit CJ
通讯作者：
Marsit CJ
女性药物滥用与创伤后应激障碍之间的联系。
DOI：
--
发表时间：
1997
期刊：
The American journal on addictions
影响因子：
--
作者：
Najavits,LM;Weiss,RD;Shaw,SR
通讯作者：
Shaw,SR
女性药物滥用与创伤后应激障碍之间的联系
影响因子：
3.7
作者：
L. Najavits;R. Weiss;Sarah R. Shaw
通讯作者：
Sarah R. Shaw
影响因子：
--
作者：
Milliren, Carly E;Gupta, Munish;Ozonoff, Al
通讯作者：
Ozonoff, Al
影响因子：
120.7
作者：
Wachman, Elisha M.;Hayes, Marie J.;Brown, Mark S.;Paul, Jonathan;Harvey-Wilkes, Karen;Terrin, Norma;Huggins, Gordon S.;Aranda, Jacob V.;Davis, Jonathan M.
通讯作者：
Davis, Jonathan M.