Feast or famine: the host-pathogen battle over amino acids.

Feast or famine: the host-pathogen battle over amino acids.
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DOI:
10.1111/cmi.12140
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发表时间:
2013-07
影响因子:
3.4
通讯作者:
Rubin EJ
Rubin EJ
中科院分区:
生物学2区
文献类型:
--
作者:
Zhang YJ;Rubin EJ

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细胞内的细菌病原体通常依赖于它们的宿主提供必需的营养。反过来,宿主细胞试图限制营养的可用性,利用饥饿作为先天免疫的机制。在这里,我们讨论了氨基酸饥饿的宿主机制和病原体对其营养缺乏环境的各种适应。这些过程为免疫颠覆和药物开发的新靶点提供了关键的见解。
Intracellular bacterial pathogens often rely on their hosts for essential nutrients. Host cells, in turn, attempt to limit nutrient availability, using starvation as a mechanism of innate immunity. Here we discuss both host mechanisms of amino acid starvation and the diverse adaptations of pathogens to their nutrient-deprived environments. These processes provide both key insights into immune subversion and new targets for drug development.
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