Detrimental effects of long sedentary bouts on the biomechanical response of cartilage to sliding
Detrimental effects of long sedentary bouts on the biomechanical response of cartilage to sliding
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长时间久坐对软骨滑动生物力学反应的不利影响
DOI：
10.1080/03008207.2019.1673382
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发表时间：
2020
影响因子：
2.9
通讯作者：
Price, Christopher
中科院分区：
文献类型：
--
作者：
Graham, Brian T.;Moore, Axel C.;Burris, David L.;Price, Christopher
目的/目标：流行病学证据表明，与流行的神话相反，增加运动/关节活动并不会增加关节软骨患病的风险，反而会促进关节健康。对此的一种解释可能是活动诱导的软骨再水化;其中关节接合驱动组织水化、厚度和依赖性摩擦力学结果的恢复（例如，载荷支撑、刚度和润滑性）损失到接头载荷。然而，目前还没有研究间歇性关节运动模式如何影响软骨的水合作用和生物力学功能。材料与方法：在这里，我们利用了收敛固定接触面积（cSCA）测试配置及其独特的摩擦再水化能力，为了阐明活动强度如何影响良好条件下牛后膝关节软骨的生物力学功能，控制滑动条件已被设计为模拟一个典型的“一天”的人类关节活动。结果：对于固定的“每日”活动量（30分钟）和久坐时间（60分钟），将间歇性活动分解为更长时间和更少频率的发作（对应于较长的连续久坐期）导致关节软骨暴露于明显更大的应变、间质压力损失和摩擦系数。这些结果表明，规律性的vivoactivity方案，特别是久坐发作的持续时间，对关节软骨的生物力学功能有显着的影响。在更实际的方面，结果表明，简短但有规律的运动模式（例如，每小时）在生物力学上可能比长时间且不频繁的运动模式（例如，久坐一天后的长距离步行）时控制日常活动量（例如，30分钟）。
Purpose/Aim: Epidemiological evidence suggests, contrary to popular mythos, that increased exercise/joint activity does not place articular cartilage at increased risk of disease, but instead promotes joint health. One explanation for this might be activity-induced cartilage rehydration; where joint articulation drives restoration of tissue hydration, thickness, and dependent tribomechanical outcomes (e.g., load support, stiffness, and lubricity) lost to joint loading. However, there have been no studies investigating how patterning of intermittent articulation influences the hydration and biomechanical functions of cartilage.Materials and Methods: Here we leveraged the convergent stationary contact area (cSCA) testing configuration and its unique ability to drive tribological rehydration, to elucidate how intermittency of activity affects the biomechanical functions of bovine stifle cartilage under well-controlled sliding conditions that have been designed to model a typical “day” of human joint activity.Results: For a fixed volume of “daily” activity (30 min) and sedentary time (60 min), breaking up intermittent activity into longer and less-frequent bouts (corresponding to longer continuous sedentary periods) resulted in the exposure of articular cartilage to markedly greater strains, losses of interstitial pressure, and friction coefficients.Conclusions: These results demonstrated that the regularity ofex vivoactivity regimens, specifically the duration of sedentary bouts, had a dominant effect on the biomechanical functions of articular cartilage. In more practical terms, the results suggest that brief but regular movement patterns (e.g., every hour) may be biomechanically preferred to long and infrequent movement patterns (e.g., a long walk after a sedentary day) when controlling for daily activity volume (e.g., 30 min).
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影响因子：
64.8
作者：
P. Walker;J. Sikorski;D. Dowson;M. Longfield;V. Wright
通讯作者：
V. Wright
影响因子：
3.9
作者：
KIM, YJ;SAH, RLY;SANDY, JD
通讯作者：
SANDY, JD
影响因子：
2.4
作者：
Bonnevie ED;Delco ML;Bartell LR;Jasty N;Cohen I;Fortier LA;Bonassar LJ
通讯作者：
Bonassar LJ
人体的故事：进化、健康和疾病。
影响因子：
1.9
作者：
D. Lieberman
通讯作者：
D. Lieberman
DOI：
10.1115/1.3168343
发表时间：
1989-02-01
影响因子：
1.7
作者：
HOU, JS;HOLMES, MH;MOW, VC
通讯作者：
MOW, VC