Phase transition characterization of poly(oligo(ethylene glycol)methyl ether methacrylate) brushes using the quartz crystal microbalance with dissipation.
Phase transition characterization of poly(oligo(ethylene glycol)methyl ether methacrylate) brushes using the quartz crystal microbalance with dissipation.
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DOI：
10.1039/d0sm02169e
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发表时间：
2021-03-11
期刊：
影响因子：
3.4
通讯作者：
Romero G
中科院分区：
文献类型：
--
作者：
Guntnur RT;Muzzio N;Morales M;Romero G
异质非线性聚（乙二醇）类似物，如聚（低聚（乙二醇）甲基醚甲基丙烯酸酯）（POEGMA），在智能生物相容性涂层的制造中特别感兴趣，因为它们响应于外部热刺激而发生可逆的大分子重排。POEGMA涂层在外部温度刺激下的相变动力学研究很少。利用耗散石英晶体微天平（QCM-D）作为聚合物刷，可以对这些功能涂层的相变进行动态、无创的原位测量。采用活性自由基聚合技术，通过改变单体分子量，在QCM-D传感器表面合成了不同厚度的POEGMA刷。从QCM-D传感器表面接枝的POEGMA刷的温敏塌陷和溶胀的研究揭示了这些涂层的可逆相变性质。此外，这些智能涂层在生物技术领域的潜力进行了探索，通过研究模型药物的吸附和解吸。从POEGMA刷观察到由温度升高触发的脉冲式药物释放曲线。POEGMA刷具有用作受控和可编程药物释放的聚合物涂层的潜力。本工作利用耗散石英晶体微天平研究了聚（低聚（乙二醇）甲基醚甲基丙烯酸酯）刷的热力学相变。聚合物刷被发现有一个可逆的相变响应于局部温度的变化。聚合物刷被用作智能药物载体。聚合物刷的药物释放遵循由温度升高触发的脉动曲线。
Heterogeneous non-linear poly(ethylene glycol) analogs, like poly (oligo (ethylene glycol) methyl ether methacrylate) (POEGMA), are of particular interest in the fabrication of smart biocompatible coatings as they undergo a reversible macromolecular rearrangement in response to external heat stimuli. The phase transition dynamics of POEGMA coatings in response to external temperature stimuli have been poorly investigated. The quartz crystal microbalance with dissipation (QCM-D) can be used to investigate the phase transition of these functional coatings as polymer brushes in a dynamic and noninvasive in situ measurement. POEGMA brushes with different thickness are synthesized from the surface of a QCM-D sensor following a living radical polymerization technique by varying the monomer molecular weight. Investigations on the thermoresponsive collapse and swelling of POEGMA brushes grafted from the surface of a QCM-D sensor reveal the reversible phase transition nature of these coating. Furthermore, the potential of these smart coatings in the field of biotechnology was explored by investigating the absorption and desorption of a model drug. A pulsatile drug release profile triggered by an increase in temperature is observed from POEGMA brushes. POEGMA brushes have the potential to be utilized as polymer coatings for controlled and programable drug release. This work investigates the thermodynamic phase transition of poly(oligo(ethylene glycol) methyl ether methacrylate) brushes using the Quartz Crystal Microbalance with Dissipation. Polymer brushes are found to have a reversible phase transition in response to local temperature changes. Polymer brushes are utilized as smart drug carriers. Drug release from polymer brushes follows a pulsatile profile triggered by the increase of temperature.
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