Adherence of Candida species to host tissues and plastic surfaces.

Adherence of Candida species to host tissues and plastic surfaces.
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念珠菌物种对宿主组织和塑料表面的粘附。

DOI:
10.1093/clinids/8.1.73
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发表时间:
1986
期刊:
Reviews of infectious diseases
影响因子:
--
通讯作者:
EdwardsJr,JE
EdwardsJr,JE
中科院分区:
--
文献类型:
--
作者:
Rotrosen,D;Calderone,RA;EdwardsJr,JE

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已在体内和体外研究了寄生虫种对宿主组织和非生物材料的粘附。白色念珠菌对粘膜细胞、纤维蛋白-血小板基质、血管内皮细胞和塑料材料的附着已被研究,以阐明粘膜定植和感染、念珠菌性心内膜炎、血管内间隙组织侵入和假体装置感染的发病机制中的早期事件。坚持C。白色念珠菌和热带念珠菌的阳性率高于其它种类,萌发念珠菌的阳性率高于其它种类。白色念珠菌细胞比酵母相生物更容易粘附于宿主组织。介导附着的粘附素的念珠菌尚未在分子水平上表征;然而,基于粗品和纯化的细胞壁产物的竞争性抑制、抗体和凝集素的阻断以及念珠菌细胞表面的受控降解,甘露聚糖和甘露糖蛋白似乎是粘附素的重要组成部分。目前用于测定药物粘附性的方法都有局限性,解决这些局限性的方法是值得进一步研究的几个领域之一。
Adherence ofCandidaspecies to host tissues and nonbiologic materials has been studied in vivo and in vitro. Attachment ofCandida albicansto mucosal cells, fibrin-platelet matrices, vascular endothelial cells, and plastic materials has been examined to elucidate early events in the pathogenesis of mucosal colonization and infection, candidal endocarditis, tissue invasion from the intravascular space, and infection of prosthetic devices. Adherence ofC. albicansandCandida tropicalisexceeds that of less virulentCandidaspecies, and germinatedC. albicanscells adhere to host tissues more readily than do yeast-phase organisms. The adhesin ofCandidathat mediates attachment has yet to be characterized at the molecular level; however, on the basis of competitive inhibition by crude and purified cell wall products, blocking by antibody and lectin, and controlled degradation of the cell surface ofCandida, it appears that mannans and mannoproteins are important constituents of the adhesin. The methods currently used to assay adherence ofCandidaall have limitations, and an approach to resolving these limitations is one of several areas that warrant further investigation.
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