APOE and APOC1 gene polymorphisms are associated with cognitive impairment progression in Chinese patients with late-onset Alzheimer's disease.
APOE and APOC1 gene polymorphisms are associated with cognitive impairment progression in Chinese patients with late-onset Alzheimer's disease.
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APOE和APOC1基因多态性与中国晚发性阿尔茨海默病患者认知障碍进展相关
DOI：
10.4103/1673-5374.130117
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发表时间：
2014-03-15
影响因子：
6.1
通讯作者：
Yang Z
中科院分区：
文献类型：
--
作者：
Zhou Q;Peng D;Yuan X;Lv Z;Pang S;Jiang W;Yang C;Shi X;Pang G;Yang Y;Xie H;Zhang W;Hu C;Yang Z
目前的证据表明载脂蛋白E（APOE）、载脂蛋白CI（APOC 1）和低密度脂蛋白受体相关蛋白（LRP）的变异与晚发性阿尔茨海默病有关。然而，目前尚不清楚这些基因的遗传多态性是否与迟发性阿尔茨海默病患者的认知能力下降有关。我们进行了一项为期30个月的纵向队列研究，以调查阿尔茨海默病与APOE，APOC 1和LRP之间的关系。在这项研究中，78例中国汉族晚发性阿尔茨海默病患者从中国广西壮族自治区招募。采用聚合酶链反应-限制性片段长度多态性进行APOE、APOC 1和LRP基因分型。采用简易精神状态检查量表和临床痴呆评定量表评定患者的认知功能。在30个月的随访期后，我们发现简易精神状态检查总分显著降低，符合认知障碍进展标准的患者比例较高，APOE ε4携带者中APOC 1 H2携带者的比例高于非携带者。此外，与非认知损害进展组相比，认知损害进展组的APOE ε4等位基因频率显著更高。结论：APOE ε4在加重认知功能减退中起重要作用，APOC 1 H2可能与APOE ε4协同作用，增加中国晚发性阿尔茨海默病患者认知功能减退的风险。
Current evidence shows that apolipoprotein E (APOE), apolipoprotein CI (APOC1) and low density lipoprotein receptor-related protein (LRP) variations are related to late-onset Alzheimer's disease. However, it remains unclear if genetic polymorphisms in these genes are associated with cognitive decline in late-onset Alzheimer's disease patients. We performed a 30-month longitudinal cohort study to investigate the relationship between Alzheimer's disease and APOE, APOC1, and LRP. In this study, 78 Chinese Han patients with late-onset Alzheimer's disease were recruited form Guangxi Zhuang Autonomous Region in China. APOE, APOC1, and LRP genotyping was performed using polymerase chain reaction-restriction fragment length polymorphisms. The Mini-Mental State Examination and Clinical Dementia Rating Scale were used to assess patients’ cognitive function. After a 30-month follow-up period, we found a significant reduction in Mini-Mental State Examination total score, a higher proportion of patients fulfilling cognitive impairment progression criteria, and a higher proportion of APOC1 H2 carriers in APOE ε4 carriers compared with non-carriers. In addition, the APOE ε4 allele frequency was significantly higher in the cognitive impairment progression group compared with the non-cognitive impairment progression group. In conclusion, APOE ε4 plays an important role in augmenting cognitive decline, and APOC1 H2 may act synergistically with APOE ε4 in increasing the risk of cognitive decline in Chinese patients with late-onset Alzheimer's disease.
影响因子：
2.3
作者：
Nagata T;Shinagawa S;Kuerban B;Shibata N;Ohnuma T;Arai H;Nakayama K;Yamada H
通讯作者：
Yamada H